Week 5 of the 2023 NFL season is here, and there are plenty of intriguing matchups to look forward to. The Jacksonville Jaguars remained abroad for their second straight London game, where they will play host to the Buffalo Bills, Nathaniel Hackett and Sean Payton come face to face when the New York Jets travel to Denver to play the Broncos, and then on Sunday night, we get what is probably the game of the week when the Dallas Cowboys take on the San Francisco 49ers.

As we do every week, we’ve collected all of the best picks and gambling content from CBSSports.com and SportsLine and put them in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. Ready? Let’s jump in.

All NFL odds via SportsLine consensus odds.

Which picks can you make with confidence in Week 5? And which Super Bowl contender goes down hard? Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up well over $7,000 for $100 players on top-rated NFL picks since its inception.

Jacksonville Jaguars at Buffalo Bills (London)

Time: Sunday, 9:30 p.m. ET (NFL Network), Stream on fubo (try for free)
Open: Bills -3.5, O/U 47.5

Katie Mox has TWO best bets for you on this matchup. She likes Bills -5.5, but also has a player prop to consider: Trevor Lawrence Under 1.5 passing touchdowns.

“Through four weeks, he’s only had four passing touchdowns total. He threw for multiple in Week 1 and that has been it. I’m not sure this is the week that he gets back to throwing a bunch of touchdowns here considering the Jags O-Line has struggled at protection and are up against a mean, mean, nasty Bills pass rush. Additionally, Buffalo is the NFL’s fourth-ranked pass defense, giving up just 169.5 passing yards per game this season. It’s just going to be tough on Lawrence in this matchup so I like him under the 1.5 passing touchdowns.” 

Mox, Will Brinson, R.J. White and Alex Selesnick broke down every NFL game this week on the Pick Six Pocast. Subscribe below for great NFL content every single day.

Baltimore Ravens at Pittsburgh Steelers

Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+ (click here)
Open: Ravens -2.5, O/U 41.5

“Gross, gross, gross. The Steelers have been terrible, particularly on offense, thanks to Matt Canada. Sheil Kapadia (friend of the Pick Six Pod) has one of the most unbelievable stats/streaks running:

“If the Steelers don’t gain 400 yards this week, they’ll be FORTY GAMES without doing it. And maybe they hit that milestone. There’s a chance this is a Mitch Trubisky-led team given the Kenny Pickett injury situation, although it appears Pickett is preparing to play. Regardless, Canada is under such insane fire, he has to basically unleash the kitchen sink in a massive home rivalry game. No one wants to back the Steelers here at all right now, the Ravens look much better, no doubt. But this is the AFC North’s ugliest battle and it usually ends up inside three points, so I’m willing to take that gamble.”

That’s CBS Sports Senior Nfl Writer Will Brinson, who is taking the Steelers to cover at home. To read his best bets for Week 5, click here.

Carolina Panthers at Detroit Lions

Time: Sunday, 1 p.m. ET (Fox), stream on fubo (try for free)
Open: Lions -7.5, O/U 44

SportsLine expert R.J. White writes a survivor strategy column every week, where he goes in depth of how you should approach your pool. He laid out multiple options for Week 5, including taking the Lions: 

“Detroit is coming off an impressive win in Green Bay with extra rest after playing on Thursday. Carolina is coming off another dismal performance by the offense with Bryce Young at QB, scoring zero touchdowns against a Vikings defense that sure didn’t seem that tough coming into the season. The Panthers were outgained by 2.4 yards per play in that matchup despite being at home against a team that typically plays indoors.”

To read White’s full analysis and check out other survivor options, head on over to SportsLine. 

Houston Texans at Atlanta Falcons

Time: Sunday, 1 p.m. ET (Fox), stream on fubo (try for free)
Open: Falcons -3.5, O/U 41.5

R.J. White has been SportsLine’s No. 1 NFL against-the-spread expert over the last six years, going 535-450-30 against the spread to put him up more than 35 units on those picks at SportsLine since 2017. He likes teasing the Texans this week.

“The Falcons come back from London after getting dominated by the Jaguars, a team the Texans beat by 20 on the road the week prior. Feels like the Texans are the better team, right? The market moved quickly when this line was Falcons -3, and it figures to stay within teaser range where we can move Houston above a touchdown. Let’s cross our fingers a +2.5 pops on the board to tease.”

To check out White’s other teaser legs this week, head on over to SportsLine. 

New Orleans Saints at New England Patriots

Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+ (click here)  
Open: Patriots -2.5, O/U 40.5

“The Patriots had no answers for a tough Cowboys pass defense, but the Saints game could prove a little different as their sack rate is mediocre on the season, which should give Mac Jones more time to get in a rhythm. The Saints inexplicably let Derek Carr play through an injury and the results were predictably awful. He’s practicing in limited fashion this week and should be on track to play again, but even if he was healthy this would be a tough road test for the longtime Raiders QB despite the Patriots losing two defenders to injury last week. The Saints offense is just 29th in yards per play and last in red zone success rate, and this should be a matchup where the Patriots can limit their opponent’s scoring and get out the door with a win, similar to the Jets game from a few weeks back.”

SportsLine expert R.J. White is taking the Patriots to win as one of his Vegas contest picks. He’s delivered a 56.5% hit rate on these picks over the last eight seasons. To check out his full set of best bets, head on over to SportsLine. 

New York Giants at Miami Dolphins

Time: Sunday, 1 p.m. ET (Fox), stream on fubo (try for free) 
Open: Dolphins -9.5, O/U 49.5

“The Giants are a mess. The offensive line is a major issue. The Dolphins have some line issues as well, but after a so-so game last week Tua Tagovailoa will get it back going right again. Dolphins big. The offense explodes again.”

CBS Sports Senior NFL Writer Pete Prisco has no problem laying the points with Miami. To read his breakdown of every game this week, click here.

Tennessee Titans at Indianapolis Colts

Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+ (click here) 
Open: Colts -1.5, O/U 42.5

“The Titans actually opened up as underdogs, but have quickly been bet up to two-point favorites. That makes me feel a bit better about this pick. It’s true that Tennessee has been terrible on the road this year (0-2, 9.0 points per game), but the Colts haven’t won a home game yet. Something has to give in this divisional showdown, and I’m going to take the team that I believe is better.

“The Titans have had the Colts’ number as of late. Tennessee has won five straight vs. Indy, and has won by an average of 9.4 points per game. Derrick Henry has been a monster in this span, rushing for 120.2 yards per game and four touchdowns. He’s coming off of his best outing of the season, rushing for 122 yards and a touchdown vs. Cincinnati. 

“Containing Anthony Richardson as a rusher and forcing him to beat you with his arm down the field is the key for Tennessee defensively, and I have faith in Mike Vrabel to do just that. The Titans are 3-1 ATS this year, so I’ll take them here.”

Jordan Dajani likes the Titans to win their first road game of the season against a division rival. To read his Week 5 column, click here. 

Cincinnati Bengals at Arizona Cardinals

Time: Sunday, 4:05 p.m. ET (Fox), stream on fubo (try for free)
Open: Bengals -7.5, O/U 42.5

“We might be on the doorstep of rock bottom for the Bengals. Joe Burrow continues to not look right and now he’ll either be without or throwing to an injured Tee Higgins (fractured rib) in this game against the Cardinals. Cincinnati has scored three or fewer points twice this season and Burrow’s 4.8 yards-per-pass-attempt average is the lowest from a quarterback since 1950 through the first four games. The Bengals have also punted on 52.3% of their drives this season, which is the highest mark in the league. While they’re struggling in Cincy, the Cardinals have been spunky! They are 3-1 ATS and I believe this could be the second time this season they pull off the upset at State Farm Stadium. Joshua Dobbs has played well in place of the recovering Kyler Murray (ACL) and I think this could be a monster day for James Conner. The Bengals are allowing 5.1 yards per rush this season. Arizona comes away with the win here and sends the Bengals further into despair.”

That’s from Tyler Sullivan, who made the Cardinals covering three points against the Bengals a best bet. To check out Sully’s other best bets in his weekly column, click here.

Philadelphia Eagles at Los Angeles Rams

Time: Sunday, 4:05 p.m. ET (Fox), stream on fubo (try for free)
Open: Eagles -6, O/U 46.5

“This feels like an obvious trap game for the Eagles: Not only do they have to fly all the way across the country, but they have to do it after playing an overtime game in Week 4. You know what, I take that back. Normally, that would be the perfect recipe for a trap game, but I haven’t cooked in three years so I don’t know the recipe for anything. 

The Rams are actually in the same exact situation as Philadelphia this week. While the Eagles were beating the Commanders in overtime, the Rams were busy beating the Colts in overtime, so it’s a clearly a trap game for both teams, which I think cancels out the possibility of a trap game. 

Although the Eagles are 4-0, they definitely don’t look as good as they did last year. Part of that has to do with the offense, but it feels like most of that has to do with the defense. Last year, the Eagles racked up 70 sacks on the season, which was tied for the third-most in a single-season in NFL history. This year, the pass rush hasn’t been as good and their secondary has taken a huge step back. 

Through four weeks, the Eagles have surrendered nine touchdown passes, which is the third-worst number in the NFL. Only the Bears and Broncos have surrendered more, and as we all know, if you’re mentioned in the same breath as the Bears and Broncos for any reason, that’s almost certainly not a good thing. 

The problem for the Eagles is that their struggling pass defense gets to face a suddenly revitalized Matthew Stafford. Last year, Stafford only had one weapon (Cooper Kupp) and when that weapon got injured, the Rams offense fell apart. This year, Kupp could be returning for this game, but even if he doesn’t, Stafford has a new favorite weapon in Puka Nacua. Puka has 39 catches this season, which not only leads the NFL, but it’s also an NFL record for the most receptions for a player through his first four games (No other player in NFL history even had 31 catches through four weeks before Puka came along). 

Thanks in large part to Puka, Stafford is averaging 307.3 passing yards per game this season, which is second in the NFL, behind only Tua Tagovailoa. 

The Rams have been surprisingly good this year and if people haven’t started noticing them yet, they will after this game.”

John Breech likes the Rams to cover the number vs. the reigning NFC champions, and actually says the Eagles are on upset alert. To read his entertaining Week 5 column, click here.

Kansas City Chiefs at Minnesota Vikings

Time: Sunday, 4:25 p.m. ET (CBS), stream on Paramount+ (click here)
Open: Chiefs -6, O/U 52

“The Vikings won last week for the first time and now get a Chiefs team playing on the road in successive weeks. The Chiefs haven’t looked great on offense this season, but the Vikings defense is the perfect tonic. Look for Patrick Mahomes to light up the aggressive Brian Flores defense.”

CBS Sports Senior NFL Writer Pete Prisco is taking the Chiefs to bounce back in a big way this weekend. To read his breakdown of every game in Week 5, click here.

New York Jets at Denver Broncos

Time: Sunday, 4:25 p.m. ET (CBS), stream on Paramount+ (click here)
Open: Broncos -3, O/U 40

How about a player prop from this matchup?

“R.J. mentioned Garrett Wilson. Love this spot for him. Going Over 58.5 receiving yards. 24 targets the last two weeks, if you looked at his target profile, which is his route participation, his air-yard share and target share, it’s elite. The problem is Zach Wilson throwing Garrett Wilson the football. But we did see some signs of life last week, now he’s playing a historically bad Broncos secondary …”

Alex Selesnick, who we know as “PropStarz,” dropped this player prop on the Pick Six Podcast this week.

Dallas Cowboys at San Francisco 49ers

Time: Sunday, 8:20 p.m. ET (NBC), stream on fubo (try for free) 
Open: 49ers -3.5, O/U 45

Before you make any Cowboys vs. 49ers picks or any other NFL predictions, you need to see which side Micah Roberts is on. Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos’ book director. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. He has a particularly keen eye for the 49ers, going 18-5 on his picks involving 49ers, returning $1250 to $100 bettors.

We can tell you he’s leaning Over the point total, but to see his against the spread pick, head on over to SportsLine.

Green Bay Packers at Las Vegas Raiders

Time: Monday, 8:15 p.m. ET (ABC/ESPN), stream on fubo (try for free) 
Open: Packers -1.5, O/U 43.5

Before you make any Packers vs. Raiders picks of your own, you need to see what NFL expert R.J. White has to say. White, a Fantasy and gambling editor for CBS Sports, consistently crushes against-the-spread picks and went 535-450-30 on his ATS picks from 2017-22, which returned more than $3,500 to $100 players. He also closed the 2022 NFL season on an incredible 107-80-6 run on his last 193 against-the-spread and total NFL picks, returning more than $1,800 for $100 bettors.

Moreover, White has a read on the pulse of the Packers. He is an amazing 60-22-2 (+3527) on his last 84 picks in games involving Green Bay! Anyone who has followed him is way up. We can tell you he’s leaning Over, but to check out his official pick, head on over to SportsLine.