The Kansas City Chiefs (4-1) have a short week and take on AFC West foe the Denver Broncos (1-4) at Arrowhead Stadium to open Week 6 on Thursday.

The Chiefs are coming off a 27-20 road win over the Minnesota Vikings. Travis Kelce had an injury scare, but returned and scored a touchdown.

The Broncos dropped their third home game of the season in the Hackett Bowl. The Jets won 31-21 as they played for offensive coordinator Nathaniel Hackett, who Broncos head coach Sean Payton insulted this summer.

The Chiefs have won 15 straight matchups against the Broncos.

Linebacker Frank Clark joined Denver this offseason after helping Kansas City win two Super Bowls. When asked about the seriousness of this matchup, he said that it isn’t a rivalry.

“A rivalry is competitive. True or false?” he said. “We have to beat the team. We have to win our division. We have to do a few things.”

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Chiefs vs. Broncos odds, moneyline, over/under

The Chiefs are favorites to defeat the Broncos, according to BetMGM NFL odds. Looking to wager? Check out the best mobile Sports Betting apps offering NFL betting promos in 2023.

• Spread: Chiefs (-10.5)
• Moneyline: Chiefs (-600); Broncos (+425)
• Over/under: 47.5

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NFL Week 6 odds, predictions and picks

Chiefs vs. Broncos | Titans vs. Ravens | Falcons vs. Commanders | Bears vs. Vikings | Bengals vs. Seahawks | Browns vs. 49ers | Texans vs. Saints | Jaguars vs. Colts | Dolphins vs. Panthers | Raiders vs. Patriots | Buccaneers vs. Lions | Rams vs. Cardinals | Jets vs. Eagles | Bills vs. Giants | Chargers vs. Cowboys

Tyler Dragon: Chiefs 28, Broncos 16

The Broncos are a mess and on the brink of a fire sale. Denver has very little chance against the defending Super Bowl champions. The Chiefs have won four in a row since losing their season opener. Kansas City surprisingly has a top-10 defense and their wide receivers are slowly improving. Patrick Mahomes targeted Rashee Rice, Kadarius Toney and Justyn Ross 15 times in Week 5.

Victoria Hernandez: Chiefs 30, Broncos 17

Are Patrick Mahomes and company the same team as last year? No. But the Broncos haven’t shown anything that would make them competitive this year in the lopsided “rivalry.” Last week, Sean Payton got served a slice of humble pie and a short turnaround doesn’t help his cause.

Safid Deen: Chiefs 27, Broncos 17

Travis Kelce could be limited by an ankle injury, but Patrick Mahomes needs to get his other playmakers involved if Kansas City is going to repeat as champs. I like the Chiefs at home against the Broncos, who feel like a dysfunctional bunch during their 1-4 start under Sean Payton. 

You can view the full list of USA TODAY’s NFL expert predictions here.

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