Severe Covid-19 is theorized to be instigated by cytokine release syndrome (CRS), which is an inflammatory immune response leading to some organ failure. Severe covid-19 and CRS have been linked with rising levels of Interleukin IL- 6 that helps in the stimulation of the liver to make C-reactive protein and fibrinogen.

Other than CRP and fibrinogen, lactate dehydrogenase and ferritin are linked with plasma IL-6 levels. Serum LDH correlated with the production of IL-18 because of the activated macrophages and elevated CD 8+ cytotoxic T cell activity in most severe and chronic pulmonary infections.

LDH also increases because of the destruction of the lymphocyte or the damage of the direct tissue from the microorganisms, tissue ischemia, and inflammation. Multiple organs are indeed affected because of Covid 19, but the most prominent organ is the lungs. Patients can also progress to respiratory distress syndrome and then develop micro thrombi or pulmonary embolism because of hypercoagulability.

To observe an increase in the risk and severity might be associated with increasing the Inflammatory Markers at the baseline and a great chance of CRP. Patients having obesity face chronic inflammation because of sustained production of cytokines in the adipose tissue and high levels of inflammatory cytokines like IL-6, CRP, and adipokines.

All manufacturing and import of the in-vitro diagnostics reagents/kits comply with the Medical device regulation India. Because of the Covid-19 effect on most body organs, patients might need testing for significant inflammatory markers like Il-6, cytokines, and CRP. The results of these tests help the physician in taking timely management of Covid-19.

Therefore, to make sure these kits are available whenever required, all the manufacturers and the importers were directed  to increase the manufacture and import of these kits to their maximum capacity that too at a fast pace.