“Dr. Califf has refused to distance himself from the F.D.A. determination to desert weak pregnant ladies to the reckless and predatory actions of the abortion business,” Mr. Daines mentioned.

5 senators who caucus with Democrats — Mr. Manchin and Senators Bernie Sanders of Vermont, Maggie Hassan of New Hampshire, Mr. Markey of Massachusetts and Richard Blumenthal of Connecticut — opposed the nomination.

Six Republicans — Senators Burr, Lisa Murkowski of Alaska, Susan Collins of Maine, Mitt Romney of Utah, Roy Blunt of Missouri and Pat Toomey of Pennsylvania — tipped the steadiness for affirmation. Of these Republicans, only one, Ms. Murkowski, is up for re-election and three — Mr. Blunt, Mr. Burr and Mr. Toomey — are retiring.

Whereas Senator Mike Rounds, Republican of South Dakota, was against the affirmation, he was marked as current as a part of a pairing with Senator Ben Ray Luján of New Mexico, who’s recovering from a stroke and would have voted “sure.”

Senator Elizabeth Warren, a Massachusetts Democrat, mentioned in an announcement that Dr. Califf secured her vote after agreeing to chorus for 4 years from in search of employment with or compensation from any drug or machine firm for 4 years after his time period as commissioner.

The incoming commissioner can have loads of work to do. The company is going through an end-run round its tobacco management authority with firms advertising artificial tobacco in flavors enticing to youngsters. Lawmakers are desirous to see adjustments in how the company fast-tracks medication to the market after the controversial approval of the Alzheimer’s drug Aduhelm. And the company has a prolonged backlog of overseas inspections to cope with, as roughly 80 percent of lively drug substances are available in from abroad.

Dr. Janet Woodcock, the interim commissioner, issued a statement on Tuesday, saying she’s going to keep on as a principal deputy on the company. She has been a goal of lawmakers who say the company spurred the opioid epidemic, which may show related as leaders flip to Congress for brand new authority to sort out a variety of points.