Two men are fighting for life and another has been seriously injured after a car crashed into a pole in Melbourne's north west.

The serious crash occurred on Sunshine Avenue in Kealba between Green Gully Road and Calverton Road about 12.45pm.

The driver and a passenger are in a critical condition, according to Victoria Police, while a second passenger has been left with serious injuries.

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All three men are believed to have upper body injuries, with a man in his 20s taken the The Alfred and the others – men in their 20s and 30s – taken to the Royal Melbourne Hospital.

Footage of the crash shows what appears to be a traffic light knocked over.

The cause of the crash is unknown.

Sunshine Avenue has been closed in both directions between Green Gully Road and Calverton Road as police investigate the incident.

VicRoads is asking motorists to follow the direction of emergency services and to use alternate routes such as Main Road East, Main Road West, Kings Road and Taylors Road or the M80 Ring Road, Keilor Park Drive and the Calder Freeway.

Buses on Route 419 are also detouring around the closure and will miss stops in the area.

Any witnesses or anyone with dash cam/CCTV is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at www.crimestoppersvic.com.au