Like everything in Excel, you can customize the way your worksheet looks by changing the color of the Gridlines to something festive.

Click the Office Button and Choose Excel Options.

Choose Advanced in the Excel Options Menu.

Scroll down to Display options for this worksheet, check Show gridlines, and choose a new color.  If you do not want gridlines at all just uncheck the Show gridlines box.

In this example I choose red.  This tip comes in handy if your looking for a better way to emphasis the grid layout.