Flooding and power cuts are possible as the storm batters the country.
The latest bad weather comes just days after Storm Ophelia killed three people in Ireland and caused disruption across the UK.
Sky News weather presenter Jo Wheeler said the disruption was likely to continue on Saturday as the storm "will bring 80mph gusts to south-western coasts".
"The other concern is that spring tides combined with large waves may lead to overtopping along southernmost coasts," she said.
"The low pressure system will then migrate northwards on Sunday taking the stronger winds with it."
This weekend's storm has not yet been christened, but the next name given to a storm will be Brian according to the Met Office's list.
Storms are named alphabetically in the UK and Storm Brian will follow September's Storm Aileen.
Hurricane Ophelia was named by the National Hurricane Centre in the US, so does not follow the same pattern.
The Met Office has issued a yellow weather warning for high winds in Wales, the South West and the South on Saturday.
"Some coastal routes and communities are likely to be affected by large waves, with potential for flooding of properties," it said.
"Some transport disruption is likely across the warning area, with delays to road, rail, air and ferry transport."
"Short term loss of power and other services is also possible."