Amoxil contains an active ingredient called Amoxicillin. It is an Ampicillin analogue that belongs to beta-lactam class of antibiotics, specifically to the Penicillin class. The drug is chemically classified as carboxylic acid trihydrate. It acts against a large number of gram-positive and gram-negative bacteria that is why it is used in the treatment of numerous Infections.

Amoxil is effective in fighting infections caused by the following bacteria:

• Escherichia coli
• Staphylococcus spp
• Alpha and beta hemolytic streptococci
• Streptococcus pneumoniae
• Haemophilus influenzae
• Proteus mirabilis
• Helicobacter pylori
• Enterococcus faecalis

Amoxicillin is not effective against strains of bacteria which produce beta-lactamase – an enzyme that degrades this drug.

Indications

Amoxil is used in the treatment of the following infections:

• Upper respiratory tract infections (pharyngitis, sinusitis, laryngitis and tonsillitis)
• Bronchitis
• Pneumonia
• Bacteriuria in pregnant women (i.e. the presence of susceptible strains of bacteria in the urine of a pregnant woman)
• Middle ear infection
• Inflammation of the serosal membrane that lines the abdominal cavity (peritonitis)
• Gynecological infections, including gonorrhea
• Stomach ulcers caused by Helicobacter pylori
• Bacterial endocarditis
• Dental abscess
• Skin and soft tissue infections
• Typhoid fever
• Urinary infections, such as cystitis and pyelonephritis

Due to the increasing number of antibiotic resistance, it is recommended to perform an antibiogram prior to the initiation of antibiotics, whereby it is desirable to wait for the antibiogram results before initiating the drug.

Precautions

Amoxil is contraindicated in patients who are allergic to Amoxicillin and other beta-lactam antibiotics, such as Ampicillin, Cephalexine, Cefazolin, Ceftazidime, Cefepime, Ceftriaxone, Cefaclor, Ceftibuten, Cefuroxime, and others. If you are experiencing any symptoms of an allergy, such as skin rash, swelling of the face, swelling of the tongue, then you should contact your doctor immediately.

Pseudomembranous colitis – an inflammation of the colon mucosa caused by the bacterium Clostridum difficile, can occur due to the use of Amoxil. Pseudomembranous colitis is usually mild, but can also be a life-threatening condition. It is therefore necessary to exclude a diagnosis of pseudomembranous colitis in patients who are experiencing diarrhea.

Amoxil should not be used in patients who have infectious mononucleosis because it has been reported that a large number of patients who suffer from this disease and take Ampicillin, develop erythematous rash.

The FDA classifies Amoxicillin into the category B because the reproductive studies in animals have not shown adverse effects of Amoxil on the fetus. However, there are no conducted clinical studies on the use of this drug in a human pregnancy. Therefore, its use during pregnancy is recommended only when clearly needed.

Amoxil is excreted in breast milk and may cause sensitization of the infant. Therefore, Amoxil should be used with the caution during the breastfeeding.

Dosage

The recommended dosage to buy Amoxicillin for adult patients is shown below:

• Mild or moderate infections of the ear, throat, or nose – 500mg twice a day or 250mg three times a day
• Severe infections of ear, throat, or nose – 875mg twice a day or 500mg three times a day
• Mild, moderate, or severe forms of acute bronchitis, chronic bronchitis, or pneumonia – 875mg twice a day or 500mg three times a day
• Mild or moderate skin infections – 500mg twice a day or 250mg three times a day
• Severe skin infections – 875 mg twice a day or 500mg three times a day
• Mild or moderate gynecological infections – 500 mg twice a day or 250 mg three times a day
• Severe gynecological infections – 875 mg twice daily or 500 mg three times daily
• Mild or moderate urinary tract infections – 500 mg twice a day or 250 mg three times a day
• Severe urinary tract infections – 875 mg twice a day or 500 mg three times a day
• Uncomplicated gonorrhea – 3000 mg (3 g) as a single dose

In some literature, the use of two doses of 3 grams is recommended for the treatment of uncomplicated urinary infections, severe purulent infections of the respiratory tract, and dental abscess in adult patients. Readily available at Meds4sure.

The usual dose for the treatment of mild infections in children older than 3 months (weighing less than 40 kg) is 12.5mg/kg twice a day; for the treatment of severe infections – 10 mg/kg three times a day. Children who weigh more than 40 kg should be dosed according to the adult recommendations. The maximum daily dosage for children under the 3 months of age is 30 mg/kg (divided into two doses), because in these children, renal function is insufficiently developed to eliminate Amoxil at the same rate as in adults.

Always consult your doctor about the dose you need to take. Doctors are the only healthcare professionals who can determine the best dose for you.

Side Effects

Possible side effects of Amoxil include:

• Nausea
• Vomiting
• Pseudomembranous colitis
• Diarrhea
• Allergic reactions, including anaphylactic shock
• Convulsions
• Dizziness
• Insomnia
• Agranulocytosis
• Leukopenia
• Anemia
• Thrombocytopenia
• Tooth discoloration
• Crystalluria
• Interstitial nephritis
• Liver damage and jaundice

Consult your physician if you notice any adverse effects.

Drug Interaction

Amoxicillin should not be used with the following drugs:

• Methotrexate – a medicine used to treat breast, skin, neck, head, and lung cancer. Amoxil can increase the concentration of Methotrexate in the blood, thus increasing the risk of side effects (anemia, bleeding, nausea, vomiting, fatigue, dizziness, and others).
• Probenecid – a medicine used to treat gout. Probeneced reduces the renal excretion of Amoxil and increases its blood concentration, and thus increasing the risk of adverse effects.
• Oral contraceptives (such as Ethinyl Estradiol/Levonorgestrel) – Amoxicillin reduces the efficacy of these drugs, which increases the risk of unwanted pregnancy.
• Allopurinol – a medicine used to treat gout. The simultaneous administration increases the risk of skin allergic reactions.
• Bacteriostatic agents, such as Chloramphenicol, Erythromycin, Azithromycin, Telithromycin, Sulfamethoxazole, Trimethoprim, Doxycycline, and Tetracycline. These drugs reduce bactericidal effects of Amoxil.

Tell your doctor about all the medicines you are taking.

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