Daniel Jones will not suit up against the Bills on Sunday, Giants coach Brian Daboll told reporters Friday.
The quarterback has been battling a Neck Injury sustained in a Week 5 loss to the Dolphins.
He left the game in the fourth quarter following a blind-side sack by Dolphins edge rusher Andrew Van Ginkel.
Jones did not practice Wednesday and Thursday.
Backup quarterback Tyrod Taylor, who played the final 12 minutes of the Dolphins loss, will get the start against the 3-2 Bills in Buffalo in a primetime game on “Sunday Night Football.”
Andrew Thomas, Matt Peart, John Michael Schmitz and Azeez Ojulari were also ruled out for the Giants, with star running back Saquon Barkley questionable to play.
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