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Lions vs. Panthers prediction, odds, spread, start time: 2023 NFL picks, Week 5 best bets from computer model

The Carolina Panthers (0-4) hit the road looking for their first win of the season when they travel to the Motor City to take on the Detroit Lions (3-1) in a Week 5 NFC matchup. The Panthers have battled injuries in 2023, and enter this matchup coming off a 21-13 home loss to the Minnesota Vikings. The Lions look to continue their push towards a NFC North title, and look to build off a dominant 34-20 win over the Green Bay Packers in Week 4. The Lions are 3-1 and the Panthers are 0-3-1 against the spread in 2023.

Kickoff is scheduled for 1 p.m. ET at Ford Field. Detroit is favored by 9.5 points in the latest Lions vs. Panthers odds, and the over/under for total points scored is 44. Before making any Lions vs. Panthers picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2023 NFL season on an incredible 168-118 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 22-10 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Lions vs. Panthers and just locked in its picks and NFL Week 5 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Panthers vs. Lions:

  • Panthers vs. Lions spread: Lions -9.5
  • Panthers vs. Lions over/under: 44 points
  • Panthers vs. Lions money line: Lions -480, Panthers +354
  • Panthers vs. Lions picks: See picks at SportsLine
  • Panthers vs. Lions live stream: fubo (try for free)

Why the Lions can cover

The Lions are the vastly superior team in this matchup and have their sights set on playoff positioning in the early season. Quarterback Jared Goff has played well for Detroit, entering this matchup completing 69.5% of his passes for 1,029 yards, six touchdowns, and three interceptions. Veteran running back David Montgomery, an offseason free agency acquisition, has been extremely productive in his first year in Detroit. In three games, the 26-year-old running back has rushed for 262 yards and five touchdowns on 69 carries. 

Defensively, the Lions have been elite at times in 2023. They enter this matchup ranked first in the NFL in rushing yards allowed per game (60.8) and fourth in total yards allowed per game (280.5). Detroit ranks seventh in the NFL in sacks (13) and 13th in points allowed per game (20.8). See which team to pick here.

Why the Panthers can cover

The Panthers are a young team in rebuilding mode, but they are playing hard for first-year head coach Frank Reich. They are still searching for their first win of the season, but haven’t played a particularly easy schedule. The Panthers have been fairly effective on the defensive side of the ball allowing 313 total yards per game. Carolina’s passing defense ranks sixth in the NFL, giving up 176.8 passing yards per game.

Rookie quarterback Bryce Young, the No. 1 overall pick in the 2023 NFL Draft, has struggled at times, but has also flashed signs of having Pro Bowl potential. Through three games, Young has completed 65% of his passes for 503 yards, two touchdowns, and two interceptions. His top target has been veteran wide receiver Adam Thielen, who enters Week 5 with 27 catches for 287 yards and two TDs. See which team to pick here.

How to make Panthers vs. Lions picks

The model has simulated Lions vs. Panthers 10,000 times and the results are in. It is leaning Under on the point total, and it also says one side of the spread hits more than 50% of the time. You can only see the model’s Lions vs. Panthers pick at SportsLine.

So who wins Panthers vs. Lions on Sunday, and which side of the spread hits more than 50% of the time? Visit SportsLine right now to see which side of the Lions vs. Panthers spread you should be all over Sunday, all from the model on a 168-118 roll on its top-rated NFL picks, and find out.

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