2015-01-04 14:05
In the female it's complicated - to the anatomy of emotions. very often women come to me and say "I have blocked tubes" or "no ovulation "or" I have cysts ". Most of them have heard of the d… Read More
Blog Directory > Health & Fitness Blogs > Hope for a child health-and-fitness Blog >
Hope For A Child Blog
molecularmedicine-geronimo.blogspot.com
Tags:
repair
dna repair
dna damage
life span
damage
span
sex dna repair
aging
protein
ros production
Hope for a child
2009-06-21 16:35
Numerous studies have been performedin mammals on the correlation betweenthe ability of cells to repair DNA andthe life span of the species from whichthe cells were taken. The life spans oft… Read More
2009-06-21 16:34
IfDNAdamage is the major cause of aging,ROS are a major source of DNA damage,and mitochondria are a major source ofROS, then animals with mitochondriaproducing higher levels of ROS mayhave a… Read More
2009-06-21 16:32
If a DNA repair pathway lacks an enzyme,but the missing enzyme is partiallycompensated for by a similar enzyme,then repair may be sufficient to allowsurvival, growth, and normal aging. While… Read More
Molecular Medicine-Premature Aging Associated With Defects In DNA Repair Or Increased Oxidant Status
2009-06-21 16:30
DNA damages are so frequent (Table 1)that total absence of DNA repair of acommon damage is likely to be incompatiblewith life. If a DNA repair pathwaylacks an essential enzyme, but the missi… Read More
2009-06-21 16:28
Table 2 lists alterations in genes controllingDNA repair, oxidant status, orapoptosis that result in increased life span.The increases in life span found withthe genetic alterations in Table… Read More
2009-06-18 17:29
Occurrence of DNA Damage and Pathwaysof DNA RepairExcept for certain viruses with an RNAgenome, the genomes of most organismsare composed of DNA. If DNA damage isthe cause of aging, thenDNAd… Read More
2009-06-18 17:28
If accumulated DNA damages are thecause of aging, then repair processeswould be less than 100% efficient; sometypes of unrepaired damages left each daywould gradually build up in nondividing… Read More
2009-06-18 17:19
The formation of amyloid fibrils plays a keyrole in the origin of several neurodegenerativepathologies, such as spongiformencephalopathies and Alzheimer’s disease.Historically, the ter… Read More
2009-06-18 17:16
The recovery of the active protein frominclusion bodies is crucial for industrialpurposes. In structural proteomicstoday, efficient production of geneticallyengineered proteins is a prerequi… Read More
2009-06-17 08:42
Inclusion bodies can form in the cytoplasmand in the periplasmic space of E. coli.Wild-type β-lactamase expressed in E. coliresults in the formation of inclusion bodiesin the periplasm… Read More
2009-06-17 08:39
Inclusion bodies were first identified inthe blood cells of patients with abnormalhemoglobins, the resulting pathology beinganemia. Pathological point mutants ofhemoglobin aggregate into inc… Read More
2009-06-17 08:38
The Formation of Inclusion BodiesThe overexpression of genes introduced inforeign hosts frequently results in aggregatednonnative proteins called inclusionbodies. In cells, inclusion bodies… Read More
2009-06-17 08:36
The discovery of a ubiquitous class ofproteins mediating the correct folding incellular environment has led to a reconsiderationof the mechanism of proteinfolding in vivo. Historically, the… Read More
2009-06-17 08:33
Molecular Crowding in the CellsThe main rules of protein folding havebeen deduced from a considerable body ofin vitro and in silico studies. It has beenaccepted that the same mechanisms arei… Read More
2009-06-16 10:38
A substantial body of information supportsthe idea that protein aggregationarises from partially folded intermediatesthrough hydrophobic interactions. Theformation of aggregates has often be… Read More
2009-06-16 10:35
Thermal unfolding of proteins is frequentlyaccompanied by the formation ofaggregates and therefore behaves as anirreversible process. It occurs at temperaturesthat vary widely according to t… Read More
2009-06-16 10:34
Transient AggregationSeveral observations indicate that transientaggregation could occur during in vitroprotein refolding. Direct evidence for the28 Aggregation, Proteintransient association… Read More
2009-06-16 10:30
The New View of Protein FoldingThe question of the mechanisms of proteinfolding has intrigued scientists formany decades. As early as the 1930s, attemptsto refold denatured proteins werepubl… Read More
2009-06-16 10:21
Protein misfolding and aggregation havebeen recognized for many years as commonprocesses. Aggregation can occurunder various conditions. The aggregationof which we are speaking is very diffe… Read More
2009-06-15 19:09
AggregatesThe association of nonnative protein molecules through intermolecular hydrophobicinteractions.Amyloid FibrilsOrdered aggregates.Inclusion BodiesInsoluble, amorphous, disordered agg… Read More
2009-06-15 19:05
Antidiabetic PPARγ Ligands Act onAdipocytesIn patients with type 2 diabetes, treatmentwith TZD compounds results in a dramaticimprovement in peripheral insulinsensitivity and a reducti… Read More
2009-06-15 19:03
The Adipocyte as a Therapeutic Target forMetabolic DiseaseAs our understanding of the importanceof adipose tissue in controllingmetabolism has grown, so too has the realizationthat therapeut… Read More
2009-06-15 19:01
The model described above proposes thatobesity promotes the development of type 2diabetes because adipocytes from obese individualshave reduced capacity for furtherlipid storage, which leads… Read More
Subscribe to Hope For A Child
Get updates delivered right to your inbox!