Congenital Malformations are structural abnormalities due to faulty development, present at birth, and are among the Major causes of prenatal, perinatal and infant mortality and morbidity. They include gross and microscopic malformations, inborn errors of metabolism, mental retardation and cellular and molecular abnormalities. About 2–3% of newborns have a single major malformation, and 0.7% have multiple major defects (Norman et al. 1995; Opitz and Wilson 1997; Aicardi 1998; Volpe 2001a).
