With the scores at 0-0 just after the hour mark, captain Ighalo stepped up from 12 yards but saw his poor spot kick kept out by home Goalkeeper Cheng Yuelei.
Three minutes later, Guangzhou scored the only goal of the game when Junior Urso headed in from a corner to continue Ighalo’s tough start to life in the CSL.
Ighalo joined Changchun in January from Watford but his new side have endured the worst possible start to the Chinese Super League season - and sit bottom of the division after two games, without a point to their name.
The 27-year-old got an opportunity to give his side the lead from the spot in the 67th minute but the Guangzhou R & F goalkeeper Cheng Yuele guessed the right way to push away Ighalo’s kick.
Changchun Yatai were trashed 5-1 to Shanghai SIPG FC; Ighalo also played the whole 90 minutes in that game and also failed to score.
Ighalo and his Changchun Yatai teammates will be looking to turn their season around when they host Shandong Luneng on Sunday, April 2.