Mike Wilkinson played basketball for the Wisconsin Badgers from 2001 to 2005. Before his career at Wisconsin, as a senior at Wisconsin Heights High School Wilkinson was named Mr. Basketball for the state of Wisconsin. During 2005, his senior season with the Badgers, Wilkinson averaged 14.3 points per game and was selected First Team All-Big Ten. He led Wisconsin to a 3rd place regular season finish in the Big Ten with an 11-5 conference record. The Badgers earned a 6-seed in the 2005 NCAA Tournament and were eventually eliminated by 2005 National Champion North Carolina in the Elite 8.

Wilkinson was not drafted in the 2005 NBA Draft but instead decided to pursue a professional career overseas. He moved to Greece and played for two years for Aris Thessaloniki. Wilkinson was selected both years to play in the Greek All-Star Games. Since then, Wilkinson has picked up a Macedonian passport and was granted citizenship which would allow him to play for the Macedonian National Basketball Team. His citizenship also makes him a hot commodity in overseas leagues since he does not count against his team's quota of American players.

Mike Wilkinson currently plays for Khimky Moscow Region in the Russian SuperLeague. Khimky is currently 14-2 and in 2nd place out of the 13 teams in the SuperLeague. Wilkinson is averaging 9.3 points and 4.8 rebounds per game so far in the 2007-08 season.