Take Marcus Rashford, who made his Europa League debut in February 2016 and took his opportunity with both hands by scoring a brace for Manchester United.
Some of this year's potential star players are Sergej Milinkovic-Savic, Mason Greenwood, Donyell Malen, Breel Embolo and Kristoffer Ajer.
Mason Greenwood set to feature in Manchester United's opening game in Group L against FC Astana at Old Trafford.
The England Under-21 international made his debut for United in their 3-1 away win against PSG, in last years Champions League round of 16.
Greenwood will hope to make a similar impact as fellow-United academy graduate Rashford who made his mark in this competition three years ago.
Malen has represented Holland at senior level scoring on his debut against Germany, in a 4-2 win at the beginning of September.
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