In his final appearance on David Letterman's Late Show three years ago, George Clooney refused to talk about his then-upcoming marriage to Amal Alamuddin.

But in his first appearance on Letterman's new Netflix talk show, My Next Guest Needs No Introduction , Clooney spoke at length about his marriage to Alamuddin — as well as his childhood in Kentucky, his activism and life as a father.

Letterman then ran through Clooney's childhood as the son of a broadcaster and former Miss Kentucky who was born in Lexington, but went to five different grade schools as the family moved around the Midwest.

While Clooney joked about the difficulty of rearing infant twins, which Alamuddin gave birth to in the summer of 2017, he and Letterman, who has a 13-year-old son, got serious about the impact of children on their lives.

After they had dinner and "talked for hours," Clooney says he began emailing her from the perspective from his dog, who said, "I'm being held hostage, and I need a lawyer to get me out of this room."

The Clooneys have since sponsored Yazidi refugee Hazim Avdal, currently a student at the University of Chicago, after his village was pillaged by ISIS.

In the latest episode of 'My Next Guest Needs No Introduction,' Letterman quizzed the actor and visited his hometown in order to learn the origins of his activism.