Manchester United XI: de Gea, Valencia, Bailly, Jones, Young, Fellaini, Matic, Mata, Mkhitaryan, Rashford, Lukaku.
The Toffees have lost three games in a row, the most recent of which was Thursday's 3-0 defeat to Atalanta in the Europa League when Koeman publicly put the onus on himself.
Following three successive defeats Koeman has called for more from his senior campaigners and after making six changes for the Europa League loss to Atalanta on Thursday, the likes of Ashley Williams, Idrissa Gueye and Davy Klaassen can be expected to be recalled along with goalkeeper Jordan Pickford.
Manchester United squad: De Gea, Romero, Valencia, Darmian, Lindelof, Bailly, Jones, Smalling, Blind, Shaw, Young, Fellaini, Matic, Herrera, Carrick, Pogba, Mata, Lingard, Mkhitaryan, Lukaku, Martial.
Everton squad: Pickford, Martina, Keane, Williams, Baines, Schneiderlin, Gueye, Klaassen, Rooney, Sigurdsson, Sandro, Stekelenburg, Jagielka, Holgate, Davies, Mirallas, Lennon, Calvert-Lewin, Vlasic, Robles, Besic, Lookman.
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