Mayfield passed for 386 yards and three touchdowns and made an early Heisman Trophy statement in leading the Sooners to the big victory on the road.
Oklahoma lost two fumbles in Ohio State territory, missed a field goal and had a drop in the red zone that could have led to more points.
The Buckeyes will still have the necessary spotlight with showdowns against Penn State and Michigan in a loaded Big Ten East, but the margin for error is low.
Now, it's on Ohio State coach Urban Meyer to make the necessary adjustments against Army and UNLV the next two weeks before Big Ten play begins.
Those are contending teams that should give the conference a path back to the College Football Playoff, which has happened only once in three seasons.
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- Mayfield with 3 TDs as No. 5 Sooners top No. 2 Ohio St 31-16Fresno Bee
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- Time to take Oklahoma -- and the Big 12 -- seriously in CFP raceESPN (blog)
- Bob Stoops, former Oklahoma coach, in Ohio Stadium for Buckeyes-Soonerscleveland.com
- Ohio State notebook: Night game brings elite recruits to ColumbusAkron Beacon Journal
- Baker Mayfield plants Oklahoma flag on Ohio State logo after Sooners whipped ...USA TODAY