With the loss Rick Porcello (8-15) snapped a string of four straight wins, surrendering a career-high 11 runs off nine hits before getting pulled in the fifth.
Things fell apart early for Porcello, the reigning AL Cy Young Award winner, who looked to be turning a corner after a poor start to 2017.
Orioles: LHP Zach Britton said before the game that an MRI on his sore left knee revealed that it is "not anything serious," adding that it is structurally in good shape.
Red Sox: Mookie Betts was back in the lineup Friday, a night after leaving in the seventh inning of Boston's loss at Cleveland with a bruised right knee after a diving catch attempt.
Manager John Farrell said Bradley (left thumb sprain) is showing improvement and doing strengthening activity.
- Red Sox notebook: Eduardo Nunez joins Dustin Pedroia on shelf after Manny ...Boston Herald
- Orioles tee off on Porcello as Red Sox lose ugly in start of series at FenwayBoston Herald
- Hanley Ramirez's role endangered by slack second-half batESPN (blog)
- Orioles-Red Sox 0825Baltimore Sun
- Orioles take advantage of Red Sox errors in 16-3 routABC News
- Baseball-Highlights of Friday's Major League Baseball gamesYahoo Sports
- The hits keep coming as O's pound Red Sox, 16-3Washington Post
- Baltimore Orioles blast Boston Red Sox behind bat of Trey ManciniNewsline
- Red Sox routed again, 16-3Lowell Sun