Milan, which beat Shkendija 6-0 in the Europa League on Thursday, started a number of its new signings but it was youth academy graduate Patrick Cutrone who made the difference.
After only four minutes, Federico Ceccherini brought down Cutrone and, after consulting with the VAR, the referee sent off the defender and awarded the visitors a penalty, which Franck Kessie converted for his first goal for his new club.
Video technology was also needed in Inter Milan's 3-0 victory over Fiorentina, which saw visiting coach Stefano Pioli return to San Siro just a few months after being fired by the Nerazzurri.
Aleksandar Kolarov, who was signed from Manchester City in July, scored a half-hour into his debut, sending a cheeky free kick under the wall and into the bottom right corner.
Eddy Anthony Salcedo Mora almost became one of the youngest goalscorers in Serie A history but the 15-year-old Genoa forward had a late chance saved in a 0-0 draw at Sassuolo.
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