The remarkable toe-Thumb Surgery took place in Beverwijk, in the Netherlands, after the patient begged surgeons to help him be able to ride his motorbike.
Hand surgeon Robert de Wijn managed with his two colleagues Mick Kreulen and Jan van Loon to transplant the Big Toe onto his hand.
The patient lost his left thumb during an accident at work in June.
The patient, who has not been named due to privacy reasons, begged for the procedure after reading about similar surgery in Sydney, Australia.
The hospital noted it is a "complicated surgery" requiring a "long recovery".
Surgeon Robert de Wijn said: "The surgery is not only about making sure the new thumb will survive, but also about reattaching the nerves and tendons making the new thumb functional too."
A hospital spokesman also noted that the "micro-surgically re-attachment of blood vessels" was a difficult feat to make sure the tissue would stay alive and the big toe would not bleed out.
De Wijn said: "You can see it as the holy grail of hand surgery."
The surgery lasted 11 hours and was deemed successful.
De Wijn said: "The patient is very satisfied and is now entering a long rehabilitation process."