Amphotericin B (AmB) is a key agent in the management of serious Systemic Fungal Infections. It was introduced in the mid- 1950s as the first effective anti-fungal drug for systemic mycoses and it has been used as the ‘‘gold standard’’ anti-fungal drug since the 1960s. AmB is a natural antibiotic belonging to the polyene group, isolated in 1955 from a strain of the Actinomycete streptomycesnodosus on soil collected in the Orinoco River region of Venezuela.
