Cassini is NASA's unmanned robotic spacecraft which was launched in collaboration with the European Space Agency and the Italian Space Agency.
The spacecraft was operated to probe Saturn and its natural satellites.
The mission, worth $3.6 billion, was launched nearly two decades ago, and later entered Saturn's orbit in 2004.
The entry pitched Cassini as the first ever spacecraft to enter the planet's orbit.
Where is Cassini now? FACT
The Saturn probe was to end by 2008, but was given extensions till 2017. With fuel running out, the spacecraft is set to make its final passes through Saturn and its rings, before destruction. At present, Cassini is around 100,000 kilometers away from Saturn.
Few hours to self-destruction: Saturn probe Cassini's final dive 15 Sep 2017
NASA's Cassini spacecraft is set to make its final dive into Saturn's orbit, before it self-destructs.
The planned crash is slated to happen at 5:25 PM IST.
Cassini had taken 453,048 images of Saturn's solar system during its lifetime.
Scientists from the Jet Propulsion Lab, which built the Saturn probe, will be monitoring Cassini during its final minutes on Saturn's atmosphere to collect data.
Cassini: The grand finale FACT
"Not only do we have an environment [at Saturn] that is just overwhelming in its abundance of scientific mysteries and puzzles, we got a spacecraft and a team that could exploit it. It's just been an amazing, amazing mission," Earl Maize, Cassini's program manager, said.