For many people, marijuana offers relief from Anxiety better than most — if not all — prescription drugs. In fact, in states like California and Colorado, anxiety is one of the most common conditions treated with cannabis. That said, weed can also have a powerful effect in the other direction— that is to say that for some, cannabis can not only trigger anxiety, but paranoia as well. The question then is: why does weed make some people feel anxious and paranoid, and leave others feeling totally relaxed and at ease? We investigate below.