The Humanized Mouse models market is projected to reach USD 128.9 million by 2022 from USD 80.3 million in 2017, at a CAGR of 9.9% during the forecast period. The humanized rat models market is expected to reach USD 8.9 million by 2022 from USD 5.9 million in 2017, at a CAGR of 8.4% during the forecast period.
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The Jackson Laboratory dominated the global cell-based humanized mouse model market in 2016. The company is a non-profit organization focusing on mammalian research and discovery of genomic solutions for preventing, treating, and curing human diseases. The company breeds and manages mice colonies and supplies them to research institutions and laboratories. It offers mice models and related services through its business segment—JAX Mice & Services. The company receives a large number of philanthropic grants to support the development of its humanized mouse model business. The company received more than 20 grants/funds from 2015 to 2018, from leading health organizations, academic institutes, and government bodies. These grants helped the company develop new models, conduct specific studies on the models, compile genome-scale data sets for mice and humans, and examine various patterns of gene expression in mice that enable a better understanding of the genetic programs responsible for normal development and disease.
In addition, the company focuses on agreements and expansions to enhance its market presence. In this regard, in 2017, The Jackson Laboratory agreed with Crown Bioscience (US) to improve the development and accessibility of innovative research models and pre-clinical services for the global biomedical research community.
Taconic Biosciences is a provider of genetically modified rats and mice models and services. The company develops customized genetically engineered, Humanized Mice Models for preclinical research studies. The company also helps clients acquire, test, develop, breed, cryopreserve, prepare, and distribute highly relevant research lines worldwide. Taconic Biosciences provides products and services to pharmaceutical and biomedical companies, government agencies, and academic institutes across Asia, North America, and Europe. The company has a network of breeding facilities and laboratory sites in the US, Germany, and Denmark.
Taconic focuses on strategic partnerships and distribution agreements as key strategies for the growth of its business. The company enters into agreements and partnership with companies and institutes that require humanized mice models for research. These strategies are aimed at increasing its customer base for humanized mouse models. For instance, in 2017, Taconic Biosciences agreed with Pharmatest Services (Finland) to develop an animal model for immune-oncology using Taconic’s huNOG model. Similarly, in March 2016, Taconic Biosciences entered into a partnership with Life Technologies (India) to provide Taconic’s mouse models and services to researchers in India and the Middle East.
Horizon Discovery Group is a leading supplier of next-generation research models, custom model generation services, and shipping containers for research models. The firm uses its proprietary technologies such as the Zinc Finger Nucleases and the CRISPR/cas9 system for genome engineering to produce complex research humanized mice models in comparatively shorter timeframes. The company invests significantly in R&D activities to launch technologically advanced products in the market. The company’s rich pool of skilled R&D personnel ensure constant development and help the company introduce advanced products in the market. It invested 25.7%, 26.3%, and 18.1% of its total revenue in R&D activities in 2016, 2015, and 2014, respectively.
The company focuses on inorganic growth strategies such as partnerships, agreements, collaborations, and acquisitions to strengthen its product portfolio. For instance, in September 2015, Horizon Discovery entered into an agreement with LakePharma, Inc. (US). Moreover, the company also acquired Sage Labs, Inc. (US). This acquisition helped Horizon Discovery to expand its range of genetically engineered preclinical models, which are important for the discovery and development of medicines.
With a diversified product portfolio of humanized mice models, wide geographical reach, and focus on inorganic strategies such as agreements and acquisitions, the company has succeeded in creating a strong foothold in the global genetic humanized mouse models market.
Other players operating in the humanized mouse market include genOway (France), Hera BioLabs (US), Harbour Antibodies (China), Crown Bioscience (US), Vitalstar Biotechnology (China), Charles River Laboratories (US), inGenious Targeting Laboratory (US), Axenis (France), TRANS GENIC (Japan), and Champions Oncology (US).
The major players in the humanized rat models market include Horizon Discovery Group plc (UK), Hera BioLabs (US), and Yecuris Corporation (US).