What is a C blood cell (Hb CC)?
The C blood genotype evolved from the A blood cell. It is formed when Lysine replaces Glutamic acid at position six of the beta hemoglobin chain. The replacement results in crystal formation of blood cells which leads to increased blood viscosity, cellular rigidity, and shortened red cell survival.
What happens when someone has CC genotype?
Hb CC is formed when Hb AC and Hb AC meets, in rare cases Hb AC and Hb SC. There are very few people living with Hb CC, this may be associated with the fact that most of them are miscarried because the Hb CC trait is associated with mild- severe cases of hemolytic anemia -a condition in which red blood cells are destroyed before their normal lifespan is over.
The lucky ones who survive are usually strong and healthy except that the have mild anaemia disorders. In vitro studies have shown that there are lower parasite multiplication rates in Hb CC which explains the protective effect of Hb CC against malaria.
Can Hb AC and Hb AC get married without worries?
Yes they can. According to the diagram, the chances of having an Hb CC child is 1:4. The child will either be miscarried or live healthy. However, even people have miscarriages due to other factors so it's worth giving it a try. Better than with AS or SC.
The C blood genotype evolved from the A blood cell. It is formed when Lysine replaces Glutamic acid at position six of the beta hemoglobin chain. The replacement results in crystal formation of blood cells which leads to increased blood viscosity, cellular rigidity, and shortened red cell survival.
What happens when someone has CC genotype?
Hb CC is formed when Hb AC and Hb AC meets, in rare cases Hb AC and Hb SC. There are very few people living with Hb CC, this may be associated with the fact that most of them are miscarried because the Hb CC trait is associated with mild- severe cases of hemolytic anemia -a condition in which red blood cells are destroyed before their normal lifespan is over.
The lucky ones who survive are usually strong and healthy except that the have mild anaemia disorders. In vitro studies have shown that there are lower parasite multiplication rates in Hb CC which explains the protective effect of Hb CC against malaria.
Can Hb AC and Hb AC get married without worries?
Yes they can. According to the diagram, the chances of having an Hb CC child is 1:4. The child will either be miscarried or live healthy. However, even people have miscarriages due to other factors so it's worth giving it a try. Better than with AS or SC.
