2019-07-29 13:00
There are a number of challenges facing pharmaceutical and biopharmaceutical companies in relation to controlling contamination in their facilities. To address some of these issues American… Read More
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pharmaceutical microbiology,quality assurance, healthcare, cleanroom, contamination control, microbiology, tim sandle, sterility, disinfection
2019-07-28 12:00
Human cells are made up of the following: a cell nucleus, which contains the genetic material in the form of DNA; and the cytoplasm, where proteins are built. In the cell nucleus, the DNA th… Read More
2019-07-27 12:00
A review of data from API inspections conducted by the EDQM between 2006 and 2018 is now available (PA/PH/CEP(18) 56 April 2019).This document summarises the trends of deficiencies observed… Read More
2019-07-26 11:30
The ISO standard for Purified water and water for injection has been update. This document specifies design, materials selection, construction and operation of Purified Water (PW) and Water… Read More
2019-07-25 09:49
The pharmaceutical industry spends its days creating medications and equipment that save lives across the country and around the globe. The entire sector is subject to the highest quality co… Read More
2019-07-24 11:30
In a new study, researchers at the University of California San Francisco, describe one of the first concrete examples of how the microbiome can interfere with a drug's intended path through… Read More
2019-07-23 11:30
Image: Dr Josehp Ndieyira of UCL MedicineThe general regulatory and scientific considerations for bispecific antibodies, is a growing area of interest.A new guidance document from… Read More
2019-07-22 13:00
The majority of contamination in a pharmaceutical facility, presuming that the air handling system is functioning as designed, that water systems are low in bioburden and are not leaking, an… Read More
2019-07-21 10:30
The European Medicines Agency (EMA) is opening up the early dialogue available through its Innovation Task Force(ITF) to all medicine developers who work on therapeutic approaches for the tr… Read More
2019-07-20 10:30
Researchers from North Carolina State University have found a gene that gives Salmonella resistance to antibiotics of last resort in a sample taken from a human patient in the U.S. The find… Read More
2019-07-19 11:30
ASTMH (American Society of Tropical Medicine and Hygiene) welcomes the WHO’s declaration of the Ebola outbreak in the Democratic Republic of the Congo as a global public health emergen… Read More
2019-07-18 12:00
Floors, often overlooked in the past as a major factor of environmental contamination leading to increased HAI rates, are, in fact, a contributor to this very expensive and life-impacting pr… Read More
2019-07-17 12:00
Regulators have a role to play in ensuring that there is a solid evidence base to support the assessment of added therapeutic benefit of novel treatments compared with existing and potential… Read More
2019-07-16 11:30
Antimicrobial paints offer the promise of extra protection against bacteria. But Northwestern University researchers caution that these paints might be doing more harm than good.In a new stu… Read More
2019-07-15 12:30
Dr Tim Sandle is currently Head of Microbiology and Sterility Assurance at Bio Products Laboratory Limited. Here he talks to the Microbiology Society about his current role, his area of rese… Read More
2019-07-14 13:00
Microscopes enhanced with artificial intelligence (AI) could help clinical microbiologists diagnose potentially deadly blood infections and improve patients' odds of survival, according to m… Read More
2019-07-12 13:02
The findings are of significance for pharmaceutical companies and the medical sector. This is in the context of a time of great struggle for antibiotic companies given the increase in i… Read More
2019-07-11 13:00
Biofilms are a structured community of bacterial cells that are adherent to inert or living surfaces. What makes these structures special is that living within these biofilm communities make… Read More
2019-07-10 11:30
Previously in this blog we mentioned the Australian TGA consultation for its Standard for Disinfectants and Sterilants (TGO 54). The consultation period has now been completed and the TGA ha… Read More
2019-07-09 12:00
The MHRA GDP Inspectorate is embarking on a pilot of a new inspection approach that will impact holders of a Wholesale Dealer’s Licence (WDA(H)) whose main activities operate from a he… Read More
2019-07-08 11:00
Efficacy is demonstrated through performance testing to show that the disinfectant is capable of reducing the microbial bioburden in either suspension (planktonic state) or from cleanroom su… Read More
2019-07-07 12:00
Image: NativeAntigenOne of virulence factors found in the influenza A viruses is hemagglutinin (HA). Researchers at Kanazawa University have recently studied the structure of HA of avian inf… Read More
2019-07-06 12:00
The slender, rod-shaped Bacillus subtilis is one of the best-studied bacteria in the world, a go-to system for exploring and understanding how bacteria grow, replicate, and divide. One of it… Read More
2019-07-05 12:00
Until now, relatively little was known about the different types of microbes found on the space station. The new approach enables researchers to identify and map different species inside the… Read More
2019-07-04 09:30
The insertion of a medical implant in a patient's body carries alongside the risk of bacterial contamination during surgery and subsequent formation of an infectious biofilm over the surface… Read More
2019-07-03 11:30
Image: William.W.Mangin-1A team led by Dr Arazoe and Prof Kuwata has devised simple and quick techniques for gene editing (target gene disruption, sequence substitution, and re-introduc… Read More
2019-07-02 11:00
The global spread of antibiotic resistance is a major public health issue and a priority for international microbiology research. In a new paper, researchers report on filming the process of… Read More
2019-07-01 11:00
Pharmaceutical Microbiology, an applied branch of Microbiology, focused on study of micro-organisms associated with the manufacture of pharmaceuticals, primarily in minimizing the numbers in… Read More
2019-06-30 10:00
Microphotograph of Ourasphaira giraldae. Image: Corentin Loron et alScientists have discovered fossils of a fungus that lived roughly one billion years ago—yes, billion—making it… Read More
2019-06-29 11:00
Image: Lucy MoralesHow do you fight a fungal infection that is becoming increasingly resistant to medicine? By starving it, found a team of University at Buffalo and Temple University resear… Read More
2019-06-28 12:30
Antibiotic resistant infection is a leading threat to public health worldwide. It has been estimated that by 2050, more people could die from infections that are no longer treatable with ant… Read More
2019-06-27 11:00
The national HIV Testing Day event organized by the Canadian AIDS Society (CAS) and community-based organizations and local health authorities across Canada is on June 27th with testing even… Read More
2019-06-26 11:00
An article of interest:Antibiotic resistance is an increasing healthcare problem worldwide. In the present study, the effects of antimicrobial photodynamic therapy (APDT) of ZnPc and ZnPc-in… Read More
2019-06-25 11:30
Global policy makers gathered at The Hague in the Netherlands for the International Ministerial Conference on antimicrobial resistance (AMR).Experts are calling for a greater focus on antibi… Read More
2019-06-24 19:56
While steam and pressure are vital factors in the efficiency of the sterilisation process, the packaging of the items is pivotal to achieve a cost-efficient autoclave cycle. Cristina Masciol… Read More
2019-06-24 11:30
In the first part of a review of HACCP methodology (“Use of Hazard Analysis and Critical Control Points (HACCP) - Part 1: Assessing microbiological risks”) the application of HAC… Read More
2019-06-23 09:30
On 1 February 2018, the European Commission published a proposal for a recast of the Directive on the quality of water intended for human consumption (the Drinking Water Directive). The prop… Read More
2019-06-22 12:00
Credit: Edward H. EgelmanA new discovery about how strange bacteria that live in soil and sediment can conduct electricity. The bacteria do so, the researchers determined, through a seamless… Read More
2019-06-21 20:00
Kamari, a project building an ecosystem of mobile gaming and lotteries with existing licenses in over seven African countries, has partnered with Kinect, a blockchain-based health technology… Read More
2019-06-21 19:54
Using paper stickers to collect pathogens on surfaces where antisepsis is required, such as in food processing plants, is easier, and less expensive than swabbing, yet similarly sensitive. "… Read More
2019-06-20 13:00
IMAGE: Tobias WüstenfeldResearchers from the European Molecular Biology Laboratory (EMBL) in Heidelberg have combined their expertise to develop a new type of microscope. The revolution… Read More
2019-06-19 12:30
The issue: Even as digital pathology makes rapid advances worldwide -- with more physicians analyzing tissue images on "smart" computers to diagnose patients -- there are no reliable standar… Read More
2019-06-18 12:30
Antimicrobial paints offer the promise of extra protection against bacteria. But Northwestern University researchers caution that these paints might be doing more harm than good.In a new stu… Read More
2019-06-16 13:00
About 10 percent of U.S. citizens have been diagnosed with diabetes, and one quarter of these patients will develop a wound that does not heal. In the worst case outcome, which occurs in up… Read More
2019-06-15 12:30
A KAIST research team developed a microfluidic-based drug screening chip that identifies synergistic interactions between two antibiotics in eight hours. This chip can be a cell-based drug s… Read More
2019-06-14 13:00
Researchers from University of Birmingham investigated how and why a clone of E. coli called ST131 -- dubbed a 'superbug' because it is resistant to multiple drugs -- has become the major ca… Read More
2019-06-13 13:00
The Bombina variegata frog, also known as Yellow Bellied Toad, inhabits the forests, grasslands, wetland, and aquatic habitats across Central Europe. Their skin secretions contain antimicrob… Read More
2019-06-12 13:00
The Nestlé Skin Health SHIELD Skin Microbiome Summit in New York showcased the rapid research developments which have been advancing in recent years. Professor Cath O’Neil of Ma… Read More
2019-06-11 12:30
In the U.S., drug companies spend more than $50 billion on R&D, while in Europe spending surpasses €30 billion. To help lower costs and to reduce the time taken for new drugs to hit… Read More
2019-06-10 11:00
Given the requirement for particle count trending it is surprising that there is little published on the subject and a paucity of examples for the reader to assess. While there are many diff… Read More
2019-06-09 11:00
Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans: A group led by Nathalie Delzenne took on the difficult task of studying a prebioti… Read More
2019-06-08 11:00
Topical application of beneficial lactobacilli and potentially other ‘live biotherapeutic products’ (LBPs) show great potential as an alternative strategy to tackle skin care pro… Read More
2019-06-07 11:00
Exposure to influential bacteria begins before we are born, new evidence confirmsAustralian researchers have laid to rest a longstanding controversy: is the womb sterile?They carefully colle… Read More
2019-06-06 19:52
New research shows that protein-based biosensors can detect the presence of a desired enzyme target and respond by physically lighting up, and enabling researchers to immediately identify ce… Read More
2019-06-05 11:30
Image: Manu5Cholesterol cannot be transported in blood on its own and is attached to hydrophilic proteins that function as transport vehicles for moving different types of fats such as… Read More
2019-06-04 11:30
Researchers have provided the first evidence that mass drug administration (MDA) can grant community-level protection against Plasmodium falciparum (P. falciparum) malaria.Their findings, pu… Read More
2019-06-03 10:30
Data integrity relates to any type of ‘data’, and the degree to which a collection of data is complete, consistent, and accurate. Data can exist in a variety of forms – as… Read More
2019-06-02 11:00
Investigators have now shown that the breast milk microbiome contains fungi. Multiple previous studies had found bacteria in breast milk. Certain fungi and bacteria have been shown to be imp… Read More
2019-06-01 11:30
Hospital patients who have methicillin-resistant Staphylococcus aureus (MRSA) can prevent future MRSA infections by following a standard bathing protocol after discharge.The Changing Lives b… Read More
2019-05-31 12:30
Imagine that HIV is a sealed tin can: if you opened it, what would you find inside? An international team led by researchers at the University of Montreal Hospital Research Centre (CRCHUM)… Read More
2019-05-30 12:00
A research team at the Department of Mechanical Engineering at Toyohashi University of Technology has developed a method to construct a biohybrid system that incorporates Vorticella microorg… Read More
2019-05-29 12:00
An interesting MHRA blog post has been posted, looking at data integrity from the GCP perspective. The blog is from Paula Walker.Here is an excerpt:“The guidance describes the need for… Read More
2019-05-28 11:00
The EMA’s safety feature provisions enter into force on 9 February 2019. Member states are required to implement the new falsified medicines safety features for almost all prescription… Read More
2019-05-27 12:00
The new and improved EudraVigilance, the European system for managing and analysing information on suspected adverse reactions to medicines that are authorised or being studied in clinical t… Read More
2019-05-26 11:00
Researchers are reporting new findings on how bacteria involved in gum disease can travel throughout the body, exuding toxins connected with Alzheimer's disease, rheumatoid arthritis and asp… Read More
2019-05-25 12:00
Bacteria in the human body are sharing genes with one another at a higher rate than is typically seen in nature, and some of those genes appear to be traveling -- independent of their microb… Read More
2019-05-24 12:30
Bacteria in the gut do far more than help digest food in the stomachs of their hosts, they can also tell the genes in their mammalian hosts what to do.A study published today in Cell describ… Read More
2019-05-23 11:00
The FDA has issued a new draft guidance document – “Nonproprietary Naming of Biological Products: Update”.This draft guidance describes FDA’s current thinking o… Read More
2019-05-22 11:00
Hundreds of different bacterial species are living inside your mouth. Some are highly abundant, while others are scarce. A few of these oral bacteria are known pathogens. Others are benign… Read More
2019-05-21 12:00
EMA and the European Directorate for the Quality of Medicines & Healthcare (EDQM) have reviewed EMA’s sampling and testing programme for centrally authorised medicines on the EU/EE… Read More
2019-05-20 11:00
Scientists report on a new method that takes advantage of engineered bacteria to produce spider silk and other difficult-to-make proteins that could be useful during future space missio… Read More
2019-05-19 11:00
A highly drug-resistant bacteria common in hospitals, Klebsiella pneumoniae, represents a significant antimicrobial resistance threat and should be monitored globally, say researchers. The w… Read More
2019-05-18 11:00
Patients with colorectal cancer have the same consistent changes in the gut bacteria across continents, cultures, and diets -- a team of international researchers find in a new study. The ho… Read More
2019-05-17 10:30
New work is helping develop a better understanding of the growing threat posed by antifungal drug resistance. Invasive aspergillosis is a devastating disease caused by breathing in small air… Read More
2019-05-17 09:55
Testing for Endotoxins and Pyrogens?Take a short survey (10 minutes) to help us understand your endotoxin and pyrogen testing needs.For the first 100 respondents, a donation of 10 € per… Read More
2019-05-16 11:30
A probiotic has been found to help weaken stubborn microbial biofilm communities in the gut that can worsen symptoms. Researchers from Case Western Reserve University report.Probiotics typic… Read More
2019-05-15 11:30
This new finding, from the Tokyo Institute of Technology, highlights the importance of microorganisms in the geochemistry of natural gas and petroleum.Hydrocarbons play key roles in atmosphe… Read More
2019-05-14 11:00
The take-up of digital pathology technology is expected to increase during the next decade and the main adopters of this technology will be healthcare organizations, such as hospitals and di… Read More
2019-05-13 12:00
When a drone is used for the first time to deliver an organ to a transplant recipient, you know big things are afoot in the pharmaceutical cold chain. So what else drives growth in this fiel… Read More
2019-05-12 17:49
Fire safety training seems like something that is just done because it’s a part of office protocol or even your home protocol, but fires are no joke and your health matters at the end… Read More
2019-05-12 16:00
Researchers have 'fine-tuned' a major cell signalling mechanism by rewriting DNA inside yeast cells to control how they respond to their environment. The study, which was published recently… Read More
2019-05-11 11:00
Antimicrobial and antifungal resistance, which describe the ability of bacteria and other pathogens to resist the effects of drugs to which they were once sensitive, is a major public health… Read More
2019-05-10 12:00
Viruses don't always kill their microbial hosts. In many cases, they develop a mutually beneficial relationship: the virus establishes itself inside the microbe and, in return, grants its ho… Read More
2019-05-09 08:00
A team of researchers including Northwestern Engineering faculty has expanded the understanding of how virus shells self-assemble, an important step toward developing techniques that use vir… Read More
2019-05-08 12:00
The European Medicines Agency (EMA) has published the final version of “Sterilisation of the medicinal product, active substance, excipient and primary container” (EMA/CHMP/CVMP/… Read More
2019-05-07 11:30
Water is a source of concern for disseminating the bacteria Legionella pneumophila and Mycobacterium avium, which cause lung disease (legionellosis and pulmonary nontuberculous mycobacterium… Read More
2019-05-06 10:00
More than one-third of healthcare workers were contaminated with multi-drug resistant organisms (MDRO) after caring for patients colonized or infected with the bacteria, according to a study… Read More
2019-05-05 12:00
Scientists at the University of Illinois at Chicago have developed a wayto identify the beginning of every gene -- known as a translation start site or a start codon -- in bacterial cell DNA… Read More
2019-05-04 11:00
The MHRA have produced an interesting blog on quality culture in the historical perspective, looking at some of the events that have shaped the development of quality (some of which have had… Read More
2019-05-03 11:00
FDA has announced the availability of a draft guidance for industry, Quality Considerations for Continuous Manufacturing, which provides information regarding FDA’s current thinking on… Read More
2019-05-02 12:30
Chemotherapy for children with acute lymphoblastic leukemia (ALL) can put them at risk for infection, often with morbid results. Researchers at St. Jude Children’s Research Hospital ha… Read More
2019-05-01 12:00
Scientists have known for a century that viruses attack and sometimes kill bacteria, much the way humans come down with the flu. But only recently have they begun to understand the biochemis… Read More
2019-04-30 13:00
There is urgent need for a new international effort to combat a global surge in poor quality and outright fake medicines that kill more than 250,000 children each year and extract some $200… Read More
2019-04-29 12:00
In the last two decades, the rate at which bacteria are becoming resistant to current antibiotic treatments has substantially increased. Antibiotic resistance is a form of drug resistance wh… Read More
2019-04-28 12:00
The number of people who become ill and die from antibiotic-resistant germs is increasing worldwide. The World Health Organization WHO sees understanding the spread of antibiotic resistance… Read More
2019-04-27 12:00
Microbiologists have discovered a new glycocin, a small antimicrobial peptide with a sugar group attached, which is produced by a thermophilic bacterium and is stable at relatively high temp… Read More
2019-04-26 12:00
Scientists have shown that different segments of a virus genome can exist in distinct cells but work together to cause an infection. This discovery upturns a fundamental model in virology th… Read More
2019-04-25 16:07
Floors, often overlooked in the past as a major factor of environmental contamination leading to increased HAI rates, are, in fact, a contributor to this very expensive and life-impacting pr… Read More
2019-04-24 13:00
New findings from a large, randomized clinical trial that compared two infection control techniques are already being incorporated into practice within the network of U.S. community hospital… Read More
2019-04-23 13:00
In an important moment for tuberculosis (TB) control, a new study finds that a shorter regimen to prevent TB can be safely co-administered with dolutegravir (DTG)—the first-line drug t… Read More
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