2023-12-02 07:19
Antibodies are a class of proteins that are important to the body’s immune system. Immunoglobulin G (IgG) stores memories of past infections and marks dangerous microbes so they can be… Read More
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Creative Biolabs Blog blogs the latest news about Creative Biolabs, frontiers in bioengineering, experimental techniques and so on.
2023-10-31 09:17
Neutralizing antibodies targeting HIV-1 Env have now been shown to protect against systemic infection. Recently, scientists from the University of Bochum in Germany and other institutions ha… Read More
2023-10-07 06:13
Immunotherapy shines in tumor treatment. In 2021, more than 100 monoclonal antibody drugs have been approved. In addition to monospecific antibodies, the development of multispecific antibod… Read More
2023-08-28 02:31
Human immunodeficiency virus 1 (HIV-1) is a retrovirus, and most HIV-1 infections occur on the mucosal surface of the human reproductive tract. After HIV-1 enters the nucleus of the host cel… Read More
2023-08-01 02:17
Therapeutic Antibody Drugs
Since the first clinical application approval in 1986, more than 100 therapeutic antibody drugs have entered clinical application successively, and new antibody dr… Read More
2023-06-30 03:10
Introduction to antibody structure and function
An antibody molecule composes of an antigen-binding fragment (Fab) and a crystallizable fragment (Fc), forming a Y-shaped structure. The Fab r… Read More
2023-06-29 07:36
G protein-coupled receptor (GPCR) is a very important receptor protein on the cell surface. In the human genome, GPCR-encoding genes account for more than 2% and contain more than 800 member… Read More
2023-06-01 06:45
Currently, the more common technical routes for lead antibody production mainly include hybridoma, antibody library, and single B cells. Among them, hybridoma technology and antibody library… Read More
2023-04-14 07:06
Basic Structure of ADCs
Antibody-drug conjugates (ADCs) are conjugates consisting of three basic components: monoclonal antibodies (which target specific tumor antigens), highly potent cytot… Read More
2023-03-27 10:31
The protein expression system is similar to a sophisticated instrument that continuously delivers proteins to the outside world. The central law is the simplest one which is that the termina… Read More
2023-02-17 08:37
This article introduces a research work published in nature structural & molecular biology. The author explores the latest progress and limitations of deep learning methods in predicting… Read More
2022-10-14 05:59
Over the past decade, the Cambridge Healthtech Institute (CHI)’s Immuno-Oncology Summit has become the leading annual meeting focusing on the latest applied research, providing compreh… Read More
2022-09-23 08:28
Following the accomplishment of the PEGS Summit, 2022 BIO International Convention, and 13th Annual World ADC, this month’s Creative Biolabs event was held this week at the DoubleTree… Read More
2022-09-07 05:59
In the past, components of adaptive immunity were thought to play non-overlapping roles in antimicrobial host defense, with antibodies targeting pathogens in the extracellular environment an… Read More
2022-08-02 02:03
The study findings, titled “Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination,” were published in Nature by a team of researchers from the University of… Read More
2022-06-20 08:10
In a new study, researchers from Emory University revealed that cancer-causing mutations result in widespread distortions in protein-protein interaction networks in cells. The findings were… Read More
2022-06-15 08:43
Following the PEGS Summit’s accomplishment, Creative Biolabs’ event of the month has launched this Monday at the San Diego Convention Center, and the exhibition at Booth #1754 wi… Read More
2022-05-26 02:41
Cancer has become the second largest health threat in the world, with about 10 million people dying of cancer in 2020. For decades, cytotoxic-based chemotherapy has been the main treatment f… Read More
2022-04-25 03:35
Even through relying on the immune system of patients, cancer immunotherapy is still far from fully utilizing the entire body’s natural defense system. In fact, most of these treatment… Read More
2022-03-16 05:33
Multiple myeloma is a largely incurable cancer of plasma cells with an extremely poor prognosis. However, in a recent study published in Science Translational Medicine entitled “Select… Read More
2022-02-21 06:27
Nuclear envelope (NE) consists of outer nuclear membrane (ONM) and inner nuclear membrane (INM), which are separated by the perinuclear space and connected at the nuclear pore complex. Inner… Read More
2022-01-12 01:44
Recently, a research paper entitled “Structural insights into the membrane microdomain organization by SPFH family proteins” was published in Cell Research. The high-resolution s… Read More
2021-12-08 02:03
Under the COVID-19 pandemic, the crisis of long-standing and equally deadly infectious diseases remains unabated. Although the death rate in 2020 is still being calculated, more than 400,000… Read More
2021-11-15 01:43
Vascular dysfunction contributes to the pro-oncogenic tumor microenvironment and impedes the delivery of therapeutic drugs, so normalizing tumor blood vessels may become a potential path. Sc… Read More
2021-10-21 03:16
In a new study, researchers from the University of Utah, Rockefeller University, and Pennsylvania State University determined how CHMP3 variants (RetroCHMP3) discovered in mice and monkeys i… Read More
2021-09-20 07:27
The identification of drug resistance mutations in drug targets provides vital information for new drug development. Due to the fallibility of HIV-1 reverse transcriptase (RT), lentivirus tr… Read More
2021-08-17 01:36
Lipid rafts are microstructural domains packed tightly in the plasma membrane and rich in cholesterol and sphingomyelin, which play an important role in many pathophysiological processes. Pr… Read More
2021-07-12 05:18
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is still spreading, with devastating consequences for human life and global economic mo… Read More
2021-06-18 07:14
Deubiquitination Enzyme Regulates the Biosynthesis of Membrane Proteins
Many proteins with hydrophobic transmembrane domain (TMD) can transfer from cytoplasm to cell membrane after translati… Read More
2021-04-12 03:04
3 Relationship Between CD47-related Signaling Pathways and Diseases
3.1 Cancer
CD47 is highly expressed on the surface of many kinds of tumor cells, which, as a signal molecule of “don… Read More
2021-04-12 02:55
2 CD47-related Signaling Pathways
The extracellular ligands interacting with CD47 are TSP1, SIRP α, and CD47 itself. Among them, little is known about the signal transduction involved… Read More
2021-04-12 02:42
Cluster of differentiation 47 (CD47) is a widely expressed glycoprotein on the cell surface, which can interact with a variety of intracellular and extracellular proteins such as thrombospon… Read More
2021-03-09 05:38
Recently, scientists at the Walter Reed Army Institute have confirmed that monoclonal antibodies can be an effective tool in the global fight against malaria.
The study, led by Dr. Sheetij… Read More
2021-02-06 06:19
In a new study, an international team led by the University of Bonn identified and further developed the novel single-domain antibodies (sdAbs) against SARS-CoV-2. The researchers also combi… Read More
2021-01-08 05:31
In a recent study, the scientists at UT Southwestern have developed a new method to study the molecular characteristics of T cells. The method, published on Nature Methods, makes it easier f… Read More
2020-12-11 01:25
Recently, the phase 3 clinical trial results of T cell receptor (TCR) therapy, tebentafusp, have been released. The results showed that it reached the primary endpoint in the treatment of me… Read More
2020-11-03 08:36
A new study published on eLife shows when T cells in the immune system find and identify targets, they release chemicals to attract more T cells, and then gather to help suppress the threat… Read More
2020-10-13 03:54
The 2020 Nobel Prize in Physiology or Medicine is awarded jointly to Harvey J. Alter, Michael Houghton and Charles M. Rice “for the discovery of Hepatitis C virus”. Thanks to the… Read More
2020-09-02 07:21
According to the latest report from the Science, four research institutions, including Massachusetts Institute of Technology and Harvard University, conducted an autopsy analysis on patients… Read More
2020-08-24 03:39
CD38 protein, which was discovered in 1980, is a type II transmembrane glycoprotein with a size of 46 kDa. The ligand of CD38 is CD31, also known as PECAM-1, which is a member of the Ig gene… Read More
2020-07-13 06:07
An important line of defense against novel coronavirus SARS-CoV-2 is the formation of neutralizing antibodies. These antibodies can eliminate invaders and have great potential in the prevent… Read More
2020-06-02 09:00
In a new study, researchers from Humabs Biomed SA and the University of Washington found that an antibody that suppresses the associated coronavirus was identified for the first time in a bl… Read More
2020-05-14 08:57
Researchers from Charité-Universitätsmedizin Berlin, Berlin Institute of Health and Deutsches Rheuma-Forschungszentrum, together with other scientists, have shown how microbes he… Read More
2020-04-27 04:10
Researchers at Harvard University studied the common cold for clues to how the COVID-19 virus might behave. They used close relatives of SARS-CoV-2 to simulate its behavior in the coming mon… Read More
2020-03-17 09:08
Nebraska is conducting the first clinical trial of possible coronavirus treatment, which is expected to eventually include 400 patients in 50 locations around the world, officials said. In t… Read More
2020-01-16 01:47
Innovation drives progress. Center for Drug Evaluation and Research (CDER) of FDA has been a strong supporter of innovation in the development of new drugs and biotherapy products. By unders… Read More
2019-12-19 04:06
In a study published in Nature, scientists from St. Jude’s Children’s Research Hospital and other institutions have developed a new treatment strategy to effectively enhance canc… Read More
2019-11-07 08:43
A team of researchers from the United States have found that an antibody that “embeds” influenza virus surface proteins can protect mice from a variety of influenza virus strains… Read More
2019-10-11 09:03
Incidence of lung cancer
Lung cancer has the highest incidence of cancer in the world. According to WHO’ statistics, there are an estimated 18.1 million new cancer patients worldwide… Read More
2019-09-17 07:07
In a study published in the international journal ACS Nano, scientists from Rutgers University have developed a new nanotechnology. It may accelerate the research in the field of stem cell t… Read More
2019-08-06 08:44
The high cost of cancer drugs makes it difficult for public and private health care systems to provide patients with up-to-date treatment. If this trend continues, it will be increasingly di… Read More
2019-07-17 03:52
According to the World Health Organization (WHO), cancer is the second leading cause of death in the world. In 2018 alone, 9.6 million people worldwide died of cancer, accounting for about 1… Read More
2019-06-19 08:01
B lymphocytes can only produce a proprietary antibody against an antigen determinant, so it has the characteristics of highly specific physical and chemical properties, single biological act… Read More
2019-05-30 08:52
The Antibodies are secreted by plasma cells transformed from B cells, and each B cell line can produce only one specific antigenic determinant. The antibody, produced from a single cell line… Read More
2019-05-16 09:09
The outbreak of Ebola in 2014 in West Africa killed more than 11000 people. At the time, scientists were working on several experimental vaccines and treatments, but none of them were approv… Read More
2019-04-25 09:15
Most CAR-T cell therapies require targeting cancer cell-specific antigens. Now, there is a new way to target the environment around the tumor, which comes from nanobodies naturally produced… Read More
2019-04-08 08:47
Melanin protects us from the sun’s destructive rays by absorbing light energy and converting it into heat. A recent study has shown that this can make it a very effective tool for tumo… Read More
2019-03-25 07:34
Scientists, from the German Cancer Research Center (DKFZ), have successfully reconstructed biomolecules in the form of images. The goal of the researchers is to create a mirror artificial pr… Read More
2019-03-04 02:18
Alzheimer’s disease (AD) is a neurodegenerative disease common in the elderly. The main pathological changes were diffuse atrophy of cerebral cortex, neurofibrillary tangles and the fo… Read More
2019-02-26 03:00
Swiss pharmaceutical giant Roche recently announced that the Food and Drug Administration (FDA) has accepted the biologics licensing application (BLA) of polatuzumab vedotin, antibody drug c… Read More
2019-02-13 08:20
French pharmaceutical giant Sanofi recently announced that the US Food and Drug Administration (FDA) has approved the nanobody drug Cablivi (caplacizumab), combined with plasma exchange and… Read More
2019-02-01 08:52
The human immunodeficiency virus (HIV) evades the body’s immune defenses through multiple mutations, and antibodies produced by the host immune system against HIV follow complex and un… Read More
2018-12-28 05:43
Immuno-Oncology Therapy (I-O) refers to a therapy that kills tumor cells by activating the body’s immune system. According to their different mechanisms of action, immunotherapeutic dr… Read More
2018-12-20 07:56
In a recent study published in an international magazine of Immunity, scientists at the University of Southampton have developed a new antibody that could hold the key to unlocking cancers&r&hell…Read More
2018-10-25 12:23
In a new study, researchers from the University of Tokyo in Japan revealed the structure of a immune protein called immunoglobulin M (IgM) by using computer image analysis and electron micro… Read More
2018-10-05 03:43
On October 3rd, the 2018 Nobel Prize in Chemistry was awarded to the field of biochemistry, in which Frances H. Arnold of US won half in recognition of her directed evolution of enzymes, and… Read More
2018-09-01 08:11
1. DotBio announced the establishment of a next-generation immuno-oncology drug based on domain antibody
DotBio, a new company focused on the development of new anti-tumor drugs for hu… Read More
2018-08-03 14:54
The International Union Against Cancer believes that one-third of cancers are preventable, one-third can be cured if diagnosed early, and one-third can be alleviated to help prolong patients… Read More
2018-07-18 08:17
On May 17, 2018, the U.S. Food and Drug Administration approved erenumab-aooe (Aimovig) for the preventive treatment of migraine in adults. Erenumab is a human monoclonal antibody… Read More
2018-07-18 07:56
Immunotherapy with checkpoint inhibitors is more effective in cancer patients who have elevated numbers of specific types of immune cells inside their tumors, a study suggests. Patient… Read More
2018-07-18 07:26
The receptors, found in so-called elite controllers who don’t need medications to keep the virus in check, suggest a new path toward immunotherapy.
Researchers trying to develop new tr… Read More
2018-07-05 02:36
Unlike the mechanism of action of traditional treatments, immunotherapy is uniquely characterized by its long-term response and survival in efficacy, unconventional delayed response and pseu… Read More
2018-06-04 05:36
In the process of discovering monoclonal antibodies, after screening antibody libraries to obtain excellent candidate molecules that can specifically bind to targets, it is necessary to enha… Read More
2018-05-07 08:30
In a groundbreaking study, researchers from the Genome Institute of Singapore (GIS) developed a new computer model of machine learning (an artificial intelligence model, AI) to accurately fi… Read More
2018-03-30 07:18
Most proteins have a tendency to form polymers, which are accompanied by slow polymer formation when they are produced, stored, transported, and injected into a patient. There are two reason… Read More
2018-03-30 03:12
Monoclonal antibodies (mAbs) — preparations of a specific type of antibody designed to bind to a single target — have shown promise in the fight against cancer and autoimmune dis… Read More
2018-03-30 02:58
Model of Factor VIII. © 3d ribbon/surface model of the human factor VIII after PDB 3CDZ. Ref.: Ngo JC, Huang M, Roth DA, Furie BC, Furie B (April 2008). DOI:10.1016/j.str.2008.03.001… Read More
2018-03-30 02:36
“Two new studies use new models to identify genetic targets and test promising treatments for adrenal cancer. One patient was treated with the immunotherapy pembrolizumab and now more… Read More
2018-03-29 08:56
Great Achievements Have Been Made in Cancer Drug Listing
In 2006-2017, a total of 89 oncology therapies (NTDs) were approved by the Center for Drug Evaluation and Research (CDER). The Biolog… Read More
2018-02-08 08:46
After more than 30 years of accumulation, monoclonal antibody drugs have become well-deserved mainstream branches in the field of medicine from targets development to technologies improvemen… Read More
2018-01-03 10:01
This is a review article published on Cell Research (2017) 27: 38-58 by Laura A Johnson and Carl H June. Dr. Carl H. June is the director of translational research at the Abra… Read More
2018-01-03 01:55
Evaluate Pharma, a well-known market research organization in the field of medicine, recently released the report “EP Vantage 2018 Preview”, in which it reviewed the new drug ap… Read More
2017-12-21 09:44
There is no doubt that this year marks the beginning of CAR-T therapy owing to the advent of two CAR-T therapies and the changes that these therapies have brought to the lives of patien… Read More
2017-12-05 07:54
A new study recently calculated the development costs of 10 new anti-tumor drugs over the 10-year period between 2006 and 2015, and found that the median development time for these 10 drugs… Read More
2017-11-22 08:03
“Brentuximab Vedotin (Antibody-drug conjugate, ADC)was approved by the FDA in 2011 as the first new therapeutic option for patients with Hodgkin lymphoma in more than 30 years. Current… Read More
2017-11-21 08:06
“An estimated 44 million people of all ages have Alzheimer’s disease (AD) in 2016, and while deaths caused by other major illnesses are continuously declining, deaths caused by n… Read More
2017-11-21 07:52
“The global biosimilar market is growing rapidly as patents on blockbuster biologic drugs expire.Although many companies are keen on getting a share in the biosimilars market given its… Read More
2017-11-06 06:36
Actemra/RoActemra® is the first FDA approved drug for treatment of serious or fatal cytokine release syndrome (CRS) caused by CAR-T therapy;
CAR-T cell therapy is an immunotherapy used t… Read More
2017-11-01 04:27
6. AstraZeneca
AstraZeneca’s research and development line was mixed last year. The Clinical Phase III trial result of Olaparib used for the treatment of BRCA mutations related advan… Read More
2017-10-31 03:03
On August 24th, a reporter was informed from Prof. Guangmei Yan research group at Zhongshan University that this group of researchers identified and gained oncolytic virus M1 synergist with… Read More
2017-10-31 03:03
On August 24th, a reporter was informed from Prof. Guangmei Yan research group at Zhongshan University that this group of researchers identified and gained oncolytic virus M1 synergist with… Read More
2017-09-29 04:29
Generally, when the business of a pharmaceutical giant reaches a plateau, its business volume won’t change much during this period. Instead, it will try to optimize its structure, incl… Read More
2017-09-29 04:29
Generally, when the business of a pharmaceutical giant reaches a plateau, its business volume won’t change much during this period. Instead, it will try to optimize its structure, incl… Read More
2017-09-11 09:45
Car-T for Autoimmune Disease
An autoimmune disease is a pathological condition resulting from an abnormal immune response to tissues that can exist in the body, affecting up to 50 million Am… Read More
2017-09-07 07:37
Chimeric antigen receptor (CAR) modified T cells (CAR-T) as a new field of adoptive immune cell therapy has become a hot spot in recent research. In 1989, Israeli scholar Gross et al. First… Read More
2017-09-04 03:58
Chimeric antigen receptor (CAR) T cells have hit the cancer immunotherapy area in the past few years.
‘A CAR therapy for cancer, using a technique called adoptive cell transfer, has be… Read More
2017-09-01 08:15
In this month, FDA oncologic Drugs Advisory Committee agreed to the approval of Novartis’s CAR-T CTL019 therapy on a vote of 10:0 for the treatment of relapsed or refractory children a… Read More
2017-09-01 02:05
Biological therapy includes a variety of models, such as immunotherapy, gene therapy, regulation of angiogenesis therapy, small molecule targeting drugs and stem cells and tissue engineering… Read More
2017-08-30 09:13
Introduction of Immunogenicity
In the description of this overview, immunogenicity is defined as the propensity of the therapeutic biologics to generate immune responses to itself and to rel… Read More
2017-08-25 10:23
Chimeric antigen receptor (CAR) modified T cells (CAR-T) as a new field of adoptive immune cell therapy has become a hot spot in recent research. In 1989, Israeli scholar Gross et al. First… Read More
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