If you are into medical research, then you will invariably encounter Peptides. These hormones are at the forefront of medical research today and many breakthrough discoveries are being made using Peptides. We at Loti Labs, always strive for excellence and affordability to provide you with the best available product on the market. Our products are of the highest quality meeting stringent tests to ensure that you receive exceptionally high-quality products.
If you are into medical research, then you will invariably encounter Peptides. These hormones are at the forefront of medical research today and many breakthrough discoveries are being made using Peptides. We at Loti Labs, always strive for excellence and affordability to provide you with the best available product on the market. Our products are of the highest quality meeting stringent tests to ensure that you receive exceptionally high-quality products.
Loti Labs is a USA based Research & Development Company.
Our laboratories produce high-quality peptides that are meant for research purposes only and are not formulated for human consumption.
SERMORELIN made by Loti Labs is a superior quality product and we can guarantee its purity.
If you are looking for information about SERMORELIN then you have come to the right place. In this article, we will inform you about this peptide, its properties, its effects and from where you can buy SERMORELIN at the best possible price.
What is SERMORELIN?
SERMORELIN is the acetate salt of an amidated synthetic 29- amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues. The free base of SERMORELIN has the empirical formula C 149 H 246 N 44 O 42 S and a molecular weight of 3,358 daltons. [6]
SERMORELIN is provided as a sterile, non-pyrogenic, lyophilized powder intended for subcutaneous injection after reconstitution with Sodium Chloride Injection, USP. The reconstituted solution has a pH of 5.0 to 5.5. SERMORELIN is available in vials.
The free base of SERMORELIN has the empirical formula C 149 H 246 N 44 O 42 S and a molecular weight of 3,358 daltons.
Structure of SERMORELIN
Molecular formula: C149H246N44O42S
Molecular Weight: 3357.9 g/mol [8]
Use of SERMORELIN
SERMORELIN is approved for the diagnostic evaluation of pituitary function and also for increasing growth in children. Off label usage may include acute or age-related growth hormone insufficiency.[5]
SERMORELIN has been used in the treatment of children with growth hormone deficiency or growth failure. Geref increases plasma growth hormone (GH) concentration by stimulating the pituitary gland to release GH. Geref is similar to the full-length native hormone (44 residues) in its ability to stimulate GH secretion in humans. It has also been used for the treatment of dwarfism and the prevention of HIV-induced weight loss. [9]
Mechanism of Action
SERMORELIN binds to the growth hormone-releasing hormone receptor and mimics native GRF in its ability to stimulate growth hormone secretion.
SERMORELIN acetate increases plasma growth hormone (GH) concentration by stimulating the pituitary gland to release GH. SERMORELIN is similar to the native hormone (GRF [1-44]-NH 2) in its ability to stimulate GH secretion in humans. [5]
Side effects
A large proportion of test subjects develop anti- GRF antibodies at least once during treatment with SERMORELIN. The significance of these antibodies is not clear and often a positive test at one growth assessment will become negative by the next assessment. The presence of antibodies does not appear to affect growth or appear to be related to a specific adverse reaction profile. No generalized allergic reactions to SERMORELIN have been reported.
The most common treatment-related adverse event (occurring in about 1 test subject in 6) is a local injection reaction characterized by pain, swelling or redness. Of 350 patients exposed to SERMORELIN in clinical trials, three discontinued therapy due to injection reactions. Other treatment-related adverse events had individual occurrence rates of less than 1% and include headache, flushing, dysphagia, dizziness, hyperactivity, somnolence and urticaria.
When administered intravenously for diagnostic use, the following adverse reactions have been noted: flushing of the face, injection site pain, redness and/or swelling, nausea, headache, vomiting, dysgeusia, pallor, and tightness in the chest.[5]
Looking for where to Buy SERMORELIN peptides?
SERMORELIN is available sterile filtered white lyophilized (freeze-dried) powder in 2 ml vials directly from Loti Labs
at a discounted price, please follow this link: https://lotilabs.com/peptides/sermorelin.html
References
- B.L. Furman, in Reference Module in Biomedical Sciences, 2017
- Mark T. Keegan, in Pharmacology and Physiology for Anesthesia, 2013
- Mark T. Keegan, in Pharmacology and Physiology for Anesthesia (Second Edition), 2019
- Mark Kester PhD, … Kent E. Vrana PhD, in Elsevier’s Integrated Review Pharmacology (Second Edition), 2012
- Zhifang Xu, in Handbook of Hormones, 2016
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