Vulvovaginal Candidiasis Vulvovaginal Candidiasis (VC) is the most common cause of infectious vaginitis, accounting for between 40% and 50% of all cases. It may cause genital discomfort, loss of productivity, reduced sexual pleasure, psychological problems, and medical expenses.[36] Seventy-five percent of reproductive-age women will have at least one episode of VC in their lifetime, and 40%