One best way to realize any chemical process is the Phase Transfer Catalysis (PTC) especially in the organic reactions. In the chemical industry, the two highly powerful diving forces are pollution prevention, as well as cost reduction and they match decisively the qualities and advantages provided by phase transfer catalysis.
The industry of pharmaceutical uses a lot of chemicals in order to create several types of medicines and drugs. Numerous enterprises of chemicals nowadays support the making of an entire shift of pharmaceutical formulations consumed by patients. There is a large number of medicines and drugs i.e., chemicals having helpful worth and utilized for the generation of pharmaceutical formulations. Compared with different industries, the pharmaceutical industry contains the significant buyers of the chemical industry.
The reasons behind why PTC is becoming the top choice of Bulk Api Manufacturers are given below.
- In the past, each successful PTC application stimulated research which in turn led to additional applications and improved processes. There is every reason to believe that this trend will continue, at least for the near future. This is also one of the reasons that it holds great importance in the pharmaceutical industry.
- The solid phase PT catalysis, consisting of PEG's covalently bonded to a metal oxide surface, has been used for the carboxymethylation of benzyl bromide to methyl phenylacetate and propylene oxide to methyl 3—hydroxybutyrate. This is very useful in pharmaceutical industry hence, it one of the reasons behind PTC importance.
- The production of synthetic organic pesticides is a multi-billion dollar industry in which PTC continues to make significant contributions. The synthetic pyrethroids, including fenvalerate, cypermethrin, and their various analogs are commercially produced utilizing PTC methods for the C—alkylation of the former type and esterification of the latter.
- The polymer chemists have enthusiastically adopted PTC and continue to utilize it for various polymer applications including monomer synthesis, polymerization, polymer modification and, in a recent development, free radical catalyst activation. PTC is particularly well adapted for condensation polymerization and, in fact, was being used for the production of polycarbonates from bis—phenate salts and phosgene even before it was recognized as a PTC example. It is probable that this is the major PTC polymer application today which holds its importance because a lot of medicines and drugs are made using polymer.
- Alkylation of sugars and carbohydrates has been an active area. PTC technique has been successfully used for the esterification of hexitols, derivatization of D—arabinofuranose, stereoselective a—glucosylation, synthesis of tetra—O—acetyl— —D—glucopyranosyl and galactopyranosyl sulfides, acetylated aryl—3—-D—gluco and galactopyranosides and 0—alkylation of carboxymethylcellulose. The industrially important alkylation of cellulose has been accomplished with benzyl and ethyl chloride as well as chloroacetic acid and acrylonitrile in the presence of Me4NCl, a Q not normally known for its efficiency in PT processes. We can speculate that stability rather than lipophilicity is important here.
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