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What is the Importance of Phase Transfer Catalyst for Various Synthetic Agents?


Phase Transfer Catalyst is a popular, well known and most used item in chemical as well as pharmaceutical industry. The foundations of PTC were laid in the late 1960s and early 1970s from the studies of Makosza(1975), Starks(1971), and Brandstrom(1977). Every successful chemical and pharmaceutical industry uses PTC in manufacturing different useful chemicals, drugs and medicines. Provided by different chemical manufacturers in India, its amazing uses and benefits make it even more important and increase its demand.
Phase Transfer Catalysis (PTC) is utilized as a part of the commercial manufacturing of more than $10 billion of chemicals each year. PTC is likewise utilized as a part of prevention of pollution, its treatment and for the impurities removal in waste and product streams. Along with this, it also plays an important role for various synthetic agents.
The Phase Transfer Catalyst (PTC) was introduced around 1965 and since then, it has become a firmly established technique in synthetic organic chemistry. Many reviews on synthetic methods that use the phase transfer catalysts have been published. One of the top concerns in using a phase transfer catalyst (PTC) in soluble form is its separation from the reaction mixture. For efficient use of the catalyst and to meet product purity requirements, synthetic techniques using PTCs involve an additional separation for catalyst isolation and product purification.

Its importance for various synthetic agents:
  • The perfumery and Fragrance Industry like Synthesis of phenylacetic acid, an intermediate in the perfumery industry (Cassar et al. 1976).  It plays a important role as a synthetic agent in the field of Pharmaceuticals such as for the synthesis of various drugs like dicyclonine, phenoperidine, oxaladine, ritaline, etc.
  • Along with the great demand of PTC in the chemical industries, it can also be used for the synthesis process for fine chemicals manufacture including the agro-chemicals, pharmaceutical, paper, dyes and so on.
  • The Polymeric bonded PTC can be used for the determination of cyanide, iodide, nitrite, sulphide and thiocyanate, led to easy layer separation and PTC-free injection of the sample into the chromatograph. 
  • Along with such amazing used of PTC as synthetic agent, one basic disadvantage of PTC, especially in commercial applications, is the need to separate the catalyst from the product organic phase.
  • The role of PTC in the field of Pharmaceuticals is important and at the point when it is used as a synthetic agent, it can improve a pharmaceutical industry a lot.





This post first appeared on Cetrimide | Phase Transfer Catalyst | Tetraethylammonium Tetrafluoroborate, please read the originial post: here

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What is the Importance of Phase Transfer Catalyst for Various Synthetic Agents?

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