Including grapes in your diet may have positive impact on your mental health as researchers have found that certain grape-derived Compounds might be developed as therapeutic agents for the treatment of Depression.

The results, published online in the journal Nature Communications, indicate that these natural compounds may reduce depression by targeting newly discovered underlying mechanisms of the disease.

“The discovery of these new, natural grape-derived polyphenol compounds targeting cellular and molecular pathways associated with inflammation may provide an effective way to treat a subset of people with depression and anxiety, a condition that affects so many people,” said lead researcher Giulio Maria Pasinetti.

Previous research has found that grape-derived polyphenols have some efficacy in modulating aspects of depression, yet the mechanisms of action had largely remained unknown until now.

The new study found that a bioactive dietary polyphenol preparation from grape was effective in promoting resilience against stress-induced depression in mice.

Specifically, the researchers found that two grape derived compounds dihydrocaffeic acid (DHCA) and malvidin-3′-O-glucoside (Mal-gluc) can promote resilience in mouse models of depression by modulating inflammation and Synaptic Plasticity, respectively.

“Our research shows that combination treatment with the two compounds can promote resilience against stress-mediated depression-like phenotypes by modulating systemic inflammatory responses and brain synaptic plasticity in a mouse model of depression,” said Jun Wang, Associate Professor at Icahn School of Medicine at Mount Sinai.

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