In an interview with The Times of India, Samantha revealed that she is deeply in love and quite happy in her relationship. She stated, "We are going very strong and I am very happy". But the actress refused to say the name of the person. Later there were rumors that her boyfriend is Siddharth, her Jabardasth movie co-star. The duo even sparked the rumors of marriage on their visit to Srikalahasti temple together, along with some of their family members
Samantha has endorsed various brands like Chik Shampoo, Gokul Sandiva, Big C Mobiles, Saravana Stores, Odonil Room Freshening Gel and Dabur Vatika Hair Oil.
Samantha is associated with a campaign supporting the children suffering from the disease Hemophilia, since October 2012. She has been attending various awareness camps by the NGO to show her support for the same, since then on. In one such event, Samantha stated, "I'm upset for two months and took break from work due to a small skin related issue. I can understand how children diagnosed with hemophilia, a cure less genetic disease feels".